Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The stat comparisons shown here clarify some strategic Cassiopeia vs. Sett matchup stats that can help us understand the differences and similarities between these two champs. As an example, Cassiopeia’s KDA ratio ([kills + assists] / deaths) of NaN is better than Sett’s ratio of NaN, highlighting that Cassiopeia may be more central to her team's team fighting capacity than Sett..
Cassiopeia often has a slightly larger longest killing spree than her enemy does. Typically, she receives less damage than Sett. This is usually reflective of different amounts of tankyness, but it can also imply that the champ with increased HP has less mobility and thus is not able to flee from further harm when poked or engaged.
Both League of Legends champions are great champions. Both have their strengths, weaknesses, and counters. In the game's current meta, Cassiopeia usually fairs equally well when facing off against Sett, with a 50.1% win rate. As a result, Cassiopeia makes an ok counter for Sett.
While Cassiopeia does have a higher winrate compared to Sett, when they face off with one another, Cassiopeia also has a much greater learning curve that makes her a more time consuming champ to develop with. You still need to be cautious when picking Cassiopeia into Settas her relative depth means you may not be able to reach her full potential without a lot of practice beforehand.
Moreover, Cassiopeia also has a good amount of utility and CC, a similar amount to Sett. This makes her just as valuable during teamfights, especially when facing champions with a ton of burst damage.
While there isn't a single best champion overall in League of Legends, in Cassiopeia vs Sett matchups, Cassiopeia is the better champion with a similar win rate, more champion depth, and a similar amount of utility to help out your allies during teamfights.
Cassiopeia is a decent counter for Sett. Focus your strategy on maximizing your gold and cs and destroying objectives. If you can do that, you should be able to stand on your own as Cassiopeia against Sett.
If you would like to learn all of the intricacies of Cassiopeia to counter Sett during both the early game and mid / late game phases of League of Legends, you should keep reading to gather a few extra lessons on this matchup. If you listen to the build and tips shown here, you will increase your win rate significantly and be that much closer to League of Legends pro players.
Cassiopeia on average picks up a similar amount of CS as Sett. Champs who typically don't earn many minion kills often don't have to have much CS to be effective, such as supports. They are capable of scaling properly off of their skills, stats, and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, typically have to have a lot of items to be effective. In either case, try to do better than the numbers displayed here to do well.
The best items to have in your Cassiopeia versus Sett build consist of Liandry's Anguish, Rylai's Crystal Scepter, and Demonic Embrace. When Cassiopeia bought at least these three pieces in her build, she performed significantly better when facing Sett than with many other commonly used counter builds. In fact, Cassiopeia had an average win rate of 50.1% when playing against Sett with this build.
To have the greatest probability of crushing Sett as Cassiopeia, Cassiopeia players should take the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Of all the rune sets players picked for Cassiopeia vs Sett counter picks, this composite of runes yielded the greatest win rate. Notably, these runes averaged a 50.1% win rate overall.
By default, tips, stats, and builds on how to beat Sett as Cassiopeia are shown for all skill levels, merged. If you want to narrow the stats and builds to a specific skill level, you can use the selection menu above.