Kai'Sa is very good at picking off isolated enemies. Stick together against her.
Make sure to place wards in your blind spots so you can see Kai'Sa coming.
Kai'Sa is very vulnerable to getting outranged by mages and long range carries.
The stat comparisons shown on this page show some significant Sett versus Kai'Sa matchup statistics that can help us explain the differences and similarities between the pair. For instance, Sett’s KDA ratio ([kills + assists] / deaths) of NaN is better than Kai'Sa’s ratio of NaN, demonstrating that Sett may be more central to his team's team fighting potential than Kai'Sa..
Sett usually has a slightly smaller longest kill spree than his counter does. On average, he receives more damage than Kai'Sa. This is usually reflective of differing health capacities, yet it can also illustrate that the champ with increased HP has less mobility and thus is not able to flee from additional damage when engaged or poked.
Both League of Legends champs are great. Both have their strengths, weaknesses, and counters. In the game's current meta, Sett usually wins when trying to fight Kai'Sa, with a 51.7% win rate. Therefore, Sett makes a good counter for Kai'Sa.
While Sett does have a higher win rate compared to Kai'Sa, when on opposite teams, Sett also has a much lower learning curve that makes him a less challenging champ to pick up and master. You should be careful when picking Sett into Kai'Sa.
Additionally, Sett has almost no amount of CC and other utility, a similar amount to Kai'Sa. This often makes her just as valuable during teamfights, especially when facing champions with a lot of burst damage.
While there isn't a single best champion overall in League of Legends, in Sett vs Kai'Sa matchups, Sett is the better champ with a higher win rate, less champion complexity, and a similar amount of utility to help out your team members during teamfights.
Sett is a decent counter to Kai'Sa. Focus your strategy on maximizing your gold income and taking out objectives. If you are able to do that, you should be able to stand on your own as Sett against Kai'Sa.
To learn all of the intricacies of Sett to counter Kai'Sa during both the laning and mid / late game phases of League of Legends, you should continue reading to learn a few extra tips and tricks for this matchup. If you listen to the build and suggestions displayed here, you will increase your win rate by a lot and be that much closer to League of Legends pro players.
Sett typically accumulates a similar amount of CS as Kai'Sa. Champions who on average don't get much CS often don't need much CS to be valuable teammates, such as support champions. They are capable of scaling properly off of their abilities and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, usually need several high cost items to be effective. In either case, try to exceed the numbers displayed here to do well.
The most important items to focus on in your Sett versus Kai'Sa build consist of Heartsteel, Sterak's Gage, and Spear Of Shojin. When Sett bought at least these three pieces in his build, he did a lot better when facing Kai'Sa than with many other common builds. In fact, Sett had an average win rate of 51.7% when countering Kai'Sa with these items in his kit.
To have the best chance of coming out on top against Kai'Sa as Sett, you should use the Conqueror, Triumph, Legend: Tenacity, Last Stand, Second Wind, and Revitalize runes from the Precision and Resolve rune sets. Of all the runes players picked for Sett vs Kai'Sa face-offs, this set of runes resulted in the best win rate. In fact, these runes averaged a 51.7% winrate overall.
By default, tips, statistics, and builds on how to beat Kai'Sa as Sett are displayed for all ranked divisions combined. If you want to scope the stats and builds to an individual player tier, you should use the selection menu above.