Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
The Cassiopeia Kai'Sa synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Kai'Sa, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Cassiopeia sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Kai'Sa. His KDA worsened from NaN to NaN. This drop shows that Kai'Sa helps Cassiopeia perform not as well in ranked League matches. Yet, the small difference demonstrates that this performance change is only marginal.
When Cassiopeia is paired with Kai'Sa, she observes a little decrease in her total damage output. This change may indicate that Kai'Sa does not help cover for her to dish out more damage or that her allyship also helps increase the game's duration. Similarly, when Cassiopeia is played with Kai'Sa on the same side, he usually scores many fewer killing sprees compared to when she plays on his own. This is contrasting evidence that she is worse when playing alongside Kai'Sa.
Additionally, when Cassiopeia plays with Kai'Sa on the same side, she typically takes a little less damage than when she plays alone. Getting dealt not as much damage may mean that Kai'Sa does a decent job of covering Cassiopeia in team fights.
There is no one best synergy for Cassiopeia that will no matter what be her best synergy. Yet, Kai'Sa is a very typical teammate for Cassiopeia. By playing on the same team as Cassiopeia, she lowers their win rate by -0.1% to 51.0%. This shows that there is a weak bond between Cassiopeia and Kai'Sa that results in them performing not as well together than without each other.
Kai'Sa has a much lower diffuclty than Cassiopeia. That means Cassiopeia players don't need to be careful when enlisting Kai'Sa comrades to fight alongside, as they will have to have a much lower level of skill to play well with you.
Playing together, Cassiopeia players should expect to witness an overall large increase in your team’s ability to deal magic damage. Together, these champs can deal quite a lot of AP type damage.
Conversely, by pairing Cassiopeia and Kai'Sa together, you will not be providing your other teammates much utility. Make sure to bring other champs on your team that neutralizes this relative hole in their abilities.
Regardless of the ability of your Kai'Sa teammate, you should focus on maximizing your income, outlasting your enemies, and taking down objectives. If you follow these simple suggestions, you should do well anyway.
To truly master Cassiopeia in order to pair well with Kai'Sa during both the early game and mid / late game phases of League games, you should continue reading to learn some more tips and tricks for this champion pairing. If you listen to the build and tips shown here, you should grow your win rate significantly.
The best items to build first in your Cassiopeia and Kai'Sa synergy build include Liandry's Anguish, Seraph's Embrace, and Rylai's Crystal Scepter. When Cassiopeia incorporated at least these three great items in her build, she performed much better as an ally of Kai'Sa than with most other typical item sets. In fact, Cassiopeia boasted an average win rate of 51.0% when synergizing her build and playstyle to Kai'Sa with these items in her kit.
To have the highest chance of crushing your oponents, you should equip the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Manaflow Band, and Transcendence runes from the Precision and Sorcery rune sets. Of all the rune combinations players picked for Cassiopeia and Kai'Sa pairings, this mix of runes resulted in the highest win rate. Moreover, these runes provided a 51.0% winrate overall.
If you need to view Cassiopeia and Kai'Sa collaboration tips and builds for a a particular division rank, please choose one from the selection menu provided above. If viewing for the first time, the statistics and tips and suggestions displayed are computed using all games with data with these champs.