LoL Senna players will find her to be a confusing champion to build out properly. You'll see that her build changes when she is up against either diversified or homogenous team comps, indicating you shouldn't follow the same Senna build every round of League of Legends
The most important items to incorporate into your champion's build are: Eklipse, Schnellfeuer-Geschütz, and Guinsoos Wutklinge. Those who included these items in their kits had a much better win rate than those who went for other Senna builds. Moreover, if you are facing a well-mixed enemy team comp, you should really consider grabbing yourself the Entschlossenheit, and Präzision runes. In recent games, she won the largest fraction of her matches when equipped with these runes.
We set our Senna build guidance by examining 92.545 recently ranked League of Legends rounds with her in them. We only propose the highest winrate Senna builds that were built by ranked players enough times for us to suggest them. With so many rounds in our dataset, we are confident in our provided builds.