LoL Vayne players may find her to be a confusing character to build out properly. You'll see that her build varies when she is playing against either well-rounded or highly focused team compositions, showing you shouldn't select the same Vayne build every single game of League of Legends
The most essential items to incorporate into your champion's build include: Schildbogen der Unsterblichkeit, Blutdürster, and Ende der Weisheit. Players who added these items in their gear had a much better winrate than those who worked towards other builds for Vayne. Likewise, if you are trying to beat a well-mixed enemy team comp, you should really consider grabbing her the Präzision, and Zauberei runes. In recent matches, she won the largest number of her games when equipped with these runes.
We calculated our Vayne build guidance by analyzing 152.804 recently ranked LoL games with her in them. We only advise the highest winrate Vayne builds that have been built by ranked League players enough times for us to propose them. With so many rounds in our dataset, we are quite confident in our recommended builds.