League of Legends Karthus players could find him to be a complex champ to build out properly. You will notice that his build changes when he is up against either diversified or specialized team comps, meaning you should not take the same Karthus build every single round of League of Legends
The best items to use in your champ's build include: Affliction de Liandry, Coiffe de Rabadon, and Bâton du vide. Those who added these items in their kits had a significantly better winrate than those who utilized other item builds for Karthus. Similarly, if you are facing a varied enemy team comp, you should really consider grabbing yourself the Inspiration, and Domination runes. In recent games, he won the greatest number of his games when equipped with these runes.
We calculated our Karthus build suggestions by analyzing 19 947 recently ranked League of Legends rounds with him in them. We only advise the best winrate Karthus builds that were used by ranked gamers enough times for us to suggest them. With so many matches in our data, we are quite confident in our provided builds.