League of Legends Kai'Sa players will likely find her to be a complex champion to build out properly. You will see that her build varies when she is up against either well-rounded or highly focused team comps, demonstrating you shouldn't take the same Kai'Sa build every round of League of Legends
The most important items to incorporate into your champ's build are: Uccisore di Kraken, Frammento d'infinito, and Bramasangue. Players who added these items in their gear had a much higher win rate than those who tried for other Kai'Sa builds. Likewise, if you are fighting a mixed enemy team comp, you should strongly consider getting her the Dominazione, and Precisione runes. In recent matches, she won the largest number of her matches when using these runes.
We came up with our Kai'Sa build suggestions by analyzing 102.153 recently ranked LoL rounds with her in them. We only propose the highest winrate Kai'Sa builds that were used by ranked players enough times for us to suggest them. With so many rounds in our dataset, we are quite confident in our provided builds.