LoL Pantheon players will find him to be a difficult champion to build out properly. You'll see that his build varies when he is fighting either diversified or specialized team compositions, showing you should not select the same Pantheon build every game of League of Legends
The most essential items to include in your champion's build include: Eclissi, Lama del re in rovina, and Rancore di Serylda. Those who included these items in their kits had a higher win rate than players who tried for other Pantheon builds. Similarly, if you are playing a well-mixed enemy team composition, you should really consider grabbing Pantheon the Precisione, and Dominazione runes. In recent games, he won the largest fraction of his rounds when using these runes.
We calculated our Pantheon build guidance by analyzing 41.238 recently ranked League of Legends games with him in them. We only recommend the highest winrate Pantheon builds that were used by ranked LoL players enough times for us to advise them. With so many games in our dataset, we are very confident in our provided builds.