League of Legends Senna players will likely find her to be a difficult character to build out properly. You'll see that her build changes when she is fighting either diversified or specialized team comps, indicating you should not follow the same Senna build every single game of League of Legends
The best items to use in your champ's build are: Eclissi, Frammento d'infinito, and Il Collezionista. Players who included these items in their kits had a greater winrate than players who used other builds for Senna. Likewise, if you are facing a well-mixed enemy team composition, you should strongly consider getting Senna the Ispirazione, and Precisione runes. In recent games, she won the largest percentage of her rounds when using these runes.
We came up with our Senna build recommendations by examining 148.431 recently ranked League rounds with her selected. We only recommend the highest winrate Senna builds that have been built by ranked gamers enough times for us to advise them. With so many matches in our dataset, we are confident in our suggested builds.