League of Legends Seraphine players will likely find her to be a confusing champ to build out properly. You will notice that her build changes when she is fighting either diversified or homogenous team compositions, indicating you shouldn't follow the same Seraphine build every game of League of Legends
The most essential items to include in your champ's build are: Regenerador de Pedra Lunar, Abraço de Seraph, and Cetro de Cristal de Rylai. Players who added these items in their setups had a much higher winrate than players who tried for other Seraphine builds. Likewise, if you are battling a mixed enemy team comp, you should really consider grabbing Seraphine the Feitiçaria, and Determinação runes. In recent games, she won the largest fraction of her matches when equipped with these runes.
We came up with our Seraphine build guidance by analyzing 65.602 recently ranked League of Legends games with her in them. We only advise the top winrate Seraphine builds that were built by ranked LoL players enough times for us to reccomend them. With so many matches in our dataset, we are quite confident in our provided builds.