LoL Karma players will find her to be a confusing champ to build out properly. You'll notice that her build varies when she is up against either generic or highly focused team comps, indicating you shouldn't follow the same Karma build every game of League of Legends
The most important items to incorporate into your champion's build are: Echos von Helia, Imperiale Verfügung, and Stab des fließenden Wassers. Players who included these pieces in their setups had a much higher winrate than players who worked towards other builds for Karma. Moreover, if you are playing a mixed enemy team arrangement, you should really consider grabbing yourself the Zauberei, and Entschlossenheit runes. In recent matches, she won the largest number of her games when equipped with these runes.
We calculated our Karma build suggestions by analyzing 69.811 recently ranked LoL games with her in them. We only propose the top winrate Karma builds that were built by ranked League players enough times for us to advise them. With so many games in our data, we are very confident in our provided builds.