The best champions out of lane to counter Seraphine include Kalista, Lucian, and Zeri. These are all great at countering Seraphine with high win rates over 57%. Even if these Seraphine counter picks are not chosen in your lane, it's not smart to take her into any of these matchups. They will usually crush Seraphine.
Yet, if the enemy team brings either Ziggs or Viktor, Seraphine mains should strongly think about choosing her, as she easily wins against these champions with win rates over 53% against each ofthem.