Karthus Build Guide

LoL Karthus Build Guide

The Best Karthus Runes, Items, and Advice to Dominate Your Competition

32,871 Karthus Builds Analyzed

Best Items for Your Karthus Build

The most important items to include in your Karthus build include: Luden's Tempest, Seraph's Embrace, Rabadon's Deathcap, and Void Staff. Yet, similar to our rune recommendations, you can also get great, dedicated, Karthus item builds further down for the specific enemy team comp you are battling in your current game. Players who added these items in their gear had a much better win rate than those who worked towards other Karthus builds.

Karthus Items to Defeat Focused Team Comps

Best Karthus Runes for Your Next Build

Dark Harvest Build Rune for Karthus Dark Harvest
Cheap Shot Build Rune for Karthus Cheap Shot
Eyeball Collection Build Rune for Karthus Eyeball Collection
Ultimate Hunter Build Rune for Karthus Ultimate Hunter
Cosmic Insight Build Rune for Karthus Cosmic Insight
Magical Footwear Build Rune for Karthus Magical Footwear
If you are playing a mixed enemy team comp, you should strongly consider getting yourself the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Cosmic Insight, and Magical Footwear runes. In recent matches, he won the largest fraction of his games when using these runes. Yet, if you are playing a more single focused enemy team composition, such as an AP focused or a crowd control heavy team, you should instead scrollbrowse below to see the best Karthus runes to win your particular match.

Karthus Runes to Beat Dedicated Enemy Teams

Dark Harvest Rune to Fight a Specific Team Comp with a Good Karthus Build Dark Harvest
Cheap Shot Rune to Fight a Specific Team Comp with a Good Karthus Build Cheap Shot
Eyeball Collection Rune to Fight a Specific Team Comp with a Good Karthus Build Eyeball Collection
Ultimate Hunter Rune to Fight a Specific Team Comp with a Good Karthus Build Ultimate Hunter
Magical Footwear Rune to Fight a Specific Team Comp with a Good Karthus Build Magical Footwear
Cosmic Insight Rune to Fight a Specific Team Comp with a Good Karthus Build Cosmic Insight

Guide to Playing with Karthus

  • Lay Waste is a powerful skillshot that takes practice to perfect. It's worth it though because it can give you a significant advantage in mid lane.
  • Wall of Pain can be used to slow down enemies during teamfights or when someone helps gank your lane.


Our Karthus builds result from our evaluation of 32,871 recently ranked Karthus rounds. Only the top winrate Karthus builds that are also in common use are recommended by us. Because we have so many rounds in our data, we are sure that we can show you high quality builds for Karthus to help ensure you win your next match!

Additionally, to view Karthus builds customized to a unique division, choose your desired division from the dropdown menu found above. If you select a different division, the proposed Karthus build given will reflect that division's meta game.

FAQs About Karthus

What is Karthus' greatest strength?

While many would argue that Karthus' greatest strength is his global Ultimate that can damage everyone, no matter where they are, we'd disagree. We believe his greatest strength is his ability to deal large amounts of AoE damage, even when dead. Karthus can continue to deal damage for a long time, even after his death. Adding Rylai's Crystal Scepter into your Karthus build can slow a large number of enemies and do more DoT. Because Karthus can deal damage even when dead, he's often not the priority of the fight. Killing him won't save them.

What is Karthus' greatest weakness?

Karthus' Q is a powerful, offensive ability with low cooldown. However, it is very skill dependent and can be dodged. Furthermore, its damage increases if only one target is hit. In teamfights and in lane, there are often other nearby enemies that dilute his single target potential. Karthus' only reliable source of damage in the middle of a teamfight is his damage aura. Use your slow to keep enemies close. To reduce the danger of diving into the enemy's back line, include Zhonya's Hourglass in your build for Karthus.

Is Karthus better in lane or in the jungle?

In the current meta, Karthus is best in the jungle. His powerful slow will help him gank while his global Ult allows him to participate in kills anywhere on the Rift. He's not just limited to a single lane or gank opportunity.