The Best Runes, Items, and Advice to Dominate Your Competition
Our Karthus builds come out of our evaluation of 122,715 recently ranked Karthus rounds. Only the best win rate Karthus builds that are also in common use are advised. Since we have so many games in our dataset, we are quite confident that we can provide high quality builds to help you win your next match!
To find more focused build advice and strategies, you should read our guide at the bottom of the page. Additionally, to see Karthus builds specific to a unique division, pick a different rank from the dropdown menu located above. If you change the selection, the ideal Karthus build will be based on that division's meta game.
Best Karthus Runes
If you are facing a mixed enemy team comp, you should really consider grabbing Karthus the Dark Harvest, Cheap Shot, Eyeball Collection, Ravenous Hunter, Nimbus Cloak, and Gathering Storm runes. In recent games, he won the greatest fraction of his games when built with these runes. However, if you are fighting a different enemy team comp, such as an AP focused or a tank heavy team, you should instead browse further down to view the best Karthus runes to win your particular round.
Versus Selected Team Comp
Best Items for Your Karthus Build
The most important items to include in your Karthus build include: Night Harvester, Rabadon's Deathcap, Void Staff, and Demonic Embrace. Moreover, like our rune suggestions, you can also get great, dedicated, Karthus item builds below for the particular enemy team comp you are facing in your ongoing match. Players who included these pieces in their setups had a much better win rate than players who tried for other Karthus builds.
vs AD Heavy Teams
vs AP Heavy Teams
vs CC Heavy Teams
vs Tanky Teams
Guide to Playing with Karthus
- Lay Waste is a powerful skillshot that takes practice to perfect. It's worth it though because it can give you a significant advantage in mid lane.
- Wall of Pain can be used to slow down enemies during teamfights or when someone helps gank your lane.