Lay Waste is a powerful skillshot that takes practice to perfect. It's worth it though because it can give you a significant advantage in mid lane.
Wall of Pain can be used to slow down enemies during teamfights or when someone helps gank your lane.
Q: What is Karthus' greatest strength?
A: While many would argue that Karthus' greatest strength is his global Ultimate that can damage everyone, no matter where they are, we'd disagree. We believe his greatest strength is his ability to deal large amounts of AoE damage, even when dead. Karthus can continue to deal damage for a long time, even after his death. Adding <a href="/item/3116/" target="_blank">Rylai's Crystal Scepter</a> into your Karthus build can slow a large number of enemies and do more DoT. Because Karthus can deal damage even when dead, he's often not the priority of the fight. Killing him won't save them.
Q: What is Karthus' greatest weakness?
A: Karthus' Q is a powerful, offensive ability with low cooldown. However, it is very skill dependent and can be dodged. Furthermore, its damage increases if only one target is hit. In teamfights and in lane, there are often other nearby enemies that dilute his single target potential. Karthus' only reliable source of damage in the middle of a teamfight is his damage aura. Use your slow to keep enemies close. To reduce the danger of diving into the enemy's back line, include <a href="/item/3157/" target=_blank">Zhonya's Hourglass</a> in your build for Karthus.
Q: Is Karthus better in lane or in the jungle?
A: In the current meta, Karthus is best in the jungle. His powerful slow will help him gank while his global Ult allows him to participate in kills anywhere on the Rift. He's not just limited to a single lane or gank opportunity.
LoL Karthus players will find him to be a difficult champion to build out properly. You will see that his build varies when he is playing against either diversified or highly focused team comps, meaning you should not take the same Karthus build every single game of League of Legends
The most important items to use in your champion's build are: Liandry's Anguish, Rabadon's Deathcap, and Demonic Embrace. Those who included these pieces in their gear had a greater win rate than those who worked towards other Karthus builds. Moreover, if you are battling a well-mixed enemy team comp, you should strongly consider getting him the Domination, and Precision runes. In recent games, he won the greatest fraction of his matches when using these runes.
We came up with our Karthus build guidance by examining 18,395 recently ranked League of Legends rounds with him selected. We only advise the highest winrate Karthus builds that have been built by ranked League players enough times for us to propose them. With so many matches in our dataset, we are confident in our recommended builds.