The Best Runes, Items, and Advice to Dominate Your Competition
We came up with our Karthus build recommendations by analyzing 35,729 recently ranked League of Legends games with him selected. We only recommend the best winrate Karthus builds that were built by ranked League players enough times for us to advise them. With so many games in our data, we are very confident in our recommended builds.
If you would like more champion specific build advice and strategies, please read our guide farther down on the page. Additionally, Karthus builds specific to a particular skill division can be displayed by selecting another division from the dropdown menu located above. The recommended Karthus build will be specific to that tier’s meta.
Best Karthus Runes
If you are battling a varied enemy team composition, you should strongly consider getting Karthus the Dark Harvest, Cheap Shot, Eyeball Collection, Ravenous Hunter, Future's Market, and Perfect Timing runes. In recent matches, he won the greatest percentage of his matches when equiped with these runes. However, if you are playing a different enemy team comp, such as an AP focused or a tank heavy team, you should instead browse below to find the best Karthus runes to defeat your particular combination of foes.
Versus Selected Team Comp
Best Items for Your Karthus Build
The most critical items to use in your Karthus build are: Liandry's Anguish, Rabadon's Deathcap, Void Staff, and Horizon Focus. Furthermore, similar to our rune builds, you can also find quality, focused, Karthus item builds further down for the specific enemy team comp you are battling in your current game. Those who included these items in their gear had a significantly better winrate than those who went for other builds for Karthus.
vs AD Heavy Teams
vs AP Heavy Teams
vs CC Heavy Teams
vs Tanky Teams
Guide to Playing with Karthus
- Lay Waste is a powerful skillshot that takes practice to perfect. It's worth it though because it can give you a significant advantage in mid lane.
- Wall of Pain can be used to slow down enemies during teamfights or when someone helps gank your lane.