LoL Seraphine players may find her to be a complex character to build out properly. You'll notice that her build is modified when she is up against either well-rounded or homogenous team compositions, showing you should not choose the same Seraphine build every single round of League of Legends
The most critical items to use in your champ's build are: Shurelya's Battlesong, Shard of True Ice, and Staff of Flowing Water. Those who included these items in their kits had a much better win rate than those who worked towards other Seraphine builds. Similarly, if you are fighting a varied enemy team composition, you should really consider grabbing her the Resolve, and Inspiration runes. In recent matches, she won the largest percentage of her rounds when equipped with these runes.
We came up with our Seraphine build suggestions by examining 66,319 recently ranked League of Legends matches with her selected. We only recommend the highest winrate Seraphine builds that were used by ranked LoL players enough times for us to reccomend them. With so many games in our dataset, we are very confident in our recommended builds.