Vladimir's ultimate, Hemoplague, is most effective when cast during teamfights on as many enemy champions as possible.
When you anticipate an engagement with your enemy lane partner, keep one stack of Bloodthirst so that you get the empowered Transfusion when you cast it.
League of Legends Vladimir players could find him to be a complex champ to build out properly. You will find that his build varies when he is up against either generic or highly focused team comps, demonstrating you shouldn't take the same Vladimir build every single game of League of Legends
The best items to incorporate into your champion's build include: Hextech Rocketbelt, Rabadon's Deathcap, and Shadowflame. Players who included these items in their gear had a much higher winrate than players who worked towards other item builds for Vladimir. Moreover, if you are trying to beat a varied enemy team composition, you should strongly consider getting him the Precision, and Sorcery runes. In recent matches, he won the largest percentage of his games when using these runes.
We set our Vladimir build suggestions by examining 44,874 recently ranked LoL rounds with him selected. We only advise the best winrate Vladimir builds that have been built by ranked players enough times for us to advise them. With so many matches in our dataset, we are confident in our suggested builds.