Use Seeds to provide vision for your team. There's no more need to blind, face-check bushies when you are Zyra.
Position your skills near Seeds to grow Thorn Spitters that deal a lot of damage.
Your Zyra Ultimate will empower your other plants. Try to use it within range of your other plants to maximize its utility. It is more than just a massive AoE knockup.
League of Legends Zyra players will likely find her to be a complex character to build out properly. You'll find that her build varies when she is fighting either generic or specialized team comps, showing you shouldn't take the same Zyra build every round of League of Legends
The most critical items to incorporate into your champ's build include: Liandry's Anguish, Shard of True Ice, and Demonic Embrace. Those who included these items in their builds had a greater win rate than those who utilized other Zyra builds. Similarly, if you are playing a well-mixed enemy team comp, you should strongly consider getting yourself the Sorcery, and Domination runes. In recent games, she won the largest fraction of her rounds when built with these runes.
We set our Zyra build suggestions by analyzing 77,725 recently ranked League of Legends rounds with her in them. We only recommend the highest winrate Zyra builds that were used by ranked gamers enough times for us to propose them. With so many matches in our data, we are quite confident in our suggested builds.