Akali excels at killing fragile champions. Let your team initiate and then strike at the people in the back.
Twilight Shroud offers safety in even the most dangerous situations. Use that time to save up energy for a quick strike later.
Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stat comparisons provided here underscore some valuable Akali vs. Vayne matchup stats that may help you figure out the distinctions between this pair of champs. As an example, Akali’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Vayne’s ratio of NaN, showing that Akali may be more central to her team's team fighting capacity than Vayne..
Akali often has a similar longest killing spree as her enemy does. Commonly, she takes more damage than Vayne. This typically indicates different amounts of tankyness, but it can also indicate that the champion with higher health has less mobility and thus is not able to escape further harm when poked or engaged.
Both League of Legends champions are great. Both have their pros and cons. In League's current meta, Akali usually fairs equally well when trying to fight Vayne, with a 49.3% win rate. Thus, Akali makes an ok counter for Vayne.
While Akali does have a lower win rate than Vayne, when they face off with one another, Akali also has a lower learning curve that makes her a less time consuming champ to learn. You still need to be cautious when picking Akali into Vayneas her relative depth means that you may not be able to unleash her full potential without a lot of practice beforehand.
Furthermore, Akali also has only a small amount of CC and other utility, a similar amount to Vayne. This often makes her just as valuable during teamfights, especially when trying to counter champions with a lot of burst damage.
While there isn't a single best champion overall in League of Legends, in Akali vs Vayne matchups, Vayne is the better champion with a similar win rate, less champion complexity, and a similar amount of utility to help out your allied champions during late stage team fights.
Akali is a somewhat poor counter to Vayne. Focus your strategy on keeping up your CS and destroying objectives. If you can do that, you should do very well as Akali against Vayne.
If you would like to learn all of the intricacies of Akali to counter Vayne during both the laning and mid / late game phases of League of Legends, you should keep reading to learn a few extra tricks and insights into this matchup. If you listen to the build and tips presented here, you will grow your win rate by a lot and be closer to League of Legends pro players.
Akali usually accumulates a similar amount of CS relative to Vayne. Champs who typically don't earn much CS often don't require much CS to be valuable teammates, such as support champions. They are capable of scaling well off of their skills, stats, and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, often have to have many items to be effective. In either case, try to surpass the values displayed on this page to do well.
The best items to prioritize in your Akali versus Vayne build include Hextech Rocketbelt, Rabadon's Deathcap, and Zhonya's Hourglass. When Akali incorporated at least these three pieces in her build, she did significantly better versus Vayne than with many other common builds. In fact, Akali boasted an average win rate of 49.3% battling Vayne with this counter build.
To have the highest chance of vanquishing Vayne as Akali, Akali players should take the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Second Wind, and Overgrowth runes from the Precision and Resolve rune sets. Of all the rune combinations players chose for Akali vs Vayne counters, this mixture of runes resulted in the best win rate. Notably, these runes gave a 49.3% winrate overall.
By default, tips, stats, and builds on how to beat Vayne as Akali are given for all ranked divisions combined. If you want to filter the statistics and builds to a particular division, you may use the selection menu above.