Target Condemn such that the enemy champion is pinned against a wall. Use this during teamfights to focus down an enemy.
Vayne is very squishy; it's important to be cautious early on and farm up items as fast as possible to help the team later.
Vayne's true damage absolutely shreds enemy tanks. In the late game, she's can take just about any champ down, quickly.
Practice your positioning. Try to keep your enemy between yourself and a wall to ensure that Condemn can stun them. Doing so can prevent the enemy from being able to engage you.
LoL Vayne players could find her to be a confusing champ to build out properly. You will find that her build is modified when she is up against either generic or highly focused team compositions, demonstrating you should not choose the same Vayne build every single round of League of Legends
The best items to use in your champion's build include: Trinity Force, Bloodthirster, and Statikk Shiv. Those who included these items in their builds had a much higher win rate than those who used other Vayne builds. Similarly, if you are trying to beat a mixed enemy team comp, you should strongly consider getting her the Precision, and Resolve runes. In recent games, she won the greatest number of her games when built with these runes.
We set our Vayne build guidance by analyzing 94,878 recently ranked League of Legends matches with her in them. We only propose the top winrate Vayne builds that have been built by ranked LoL players enough times for us to advise them. With so many games in our dataset, we are quite confident in our provided builds.