Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Zilean is fragile if a team focuses on him, but otherwise he's very difficult to kill. Commit to killing him as a team.
If you're able to match Zilean's speed, it can sometimes be beneficial to wait until his ultimate has faded before landing the killing blow.
The stats shown on this page clarify several influential Cassiopeia against Zilean counter statistics that can help you grasp the differences between the two. As an example, Cassiopeia’s KDA ratio ([kills + assists] / deaths) of NaN is more than Zilean’s ratio of NaN, demonstrating that Cassiopeia may be more central to her team's team fighting effectiveness than Zilean. This observation is largely caused by the difference in kills.
Cassiopeia normally has a much larger longest kill spree than her matchup does. Typically, she takes more damage than Zilean. This often reflects different amounts of tankyness; however, it can also imply that the one champ has less mobility and thus is not able to flee from additional damage when engaged or poked.
Both LoL champions are great. Both champs have their pros and cons. In League's current meta, Cassiopeia usually wins when facing off against Zilean, with a 51.3% win rate. As a result, Cassiopeia makes a good counter to Zilean.
While Cassiopeia does have a higher win rate compared to Zilean, when on opposite teams, Cassiopeia also has a much greater difficulty level that makes her a more complex champion to learn and master. You should be careful when picking Cassiopeia into Zileanas her relative depth means that you may not be able to reach her full potential without a significant amount of practice beforehand.
Moreover, Cassiopeia also has a good amount of utility and CC, a similar amount to Zilean. This makes her just as valuable during team fights, especially when facing champions with a ton of burst damage.
While there is not one best champion for every situation in League of Legends, in Cassiopeia vs Zilean matchups, Cassiopeia is the better champion with a higher win rate, more champion depth, and a similar amount of utility to help out your allied champions during teamfights.
Cassiopeia is a decent counter for Zilean. You will do well by focussing your strategy on keeping up your gold and cs and clearing objectives. If you are able to do that, you should hold your own as Cassiopeia against Zilean.
If you would like to learn all of the intricacies of Cassiopeia to counter Zilean during both the lane and mid / late game phases of League of Legends, you should keep reading to gather a few extra tricks and insights into this matchup. If you pay attention to the build and tips shown here, you will increase your win rate by a lot and be closer to League of Legends pro players.
Cassiopeia most often picks up much more CS compared to Zilean. Champs who on average don't earn many minion kills typically don't have to have much CS to be valuable teammates, such as sup champs. These kinds of champions are capable of scaling properly off of their skills, stats, and first items alone. Yet, champions with a lot of CS, such as hyper-carries, usually have to have many items to be effective. In either case, try to do better than the values reported here to do well.
The top items to focus on in your Cassiopeia versus Zilean build consist of Liandry's Anguish, Seraph's Embrace, and Rylai's Crystal Scepter. When Cassiopeia bought at least these three items in her build, she performed much better vs Zilean than with many other commonly used counter builds. In fact, Cassiopeia boasted an average winrate of 51.3% when playing against Zilean with this counter build.
To have the best likelihood of defeating Zilean as Cassiopeia, you should equip the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Of all the rune sets players picked for Cassiopeia vs Zilean face-offs, this combo of runes resulted in the greatest win rate. Notably, these runes averaged a 51.3% win rate overall.
By default, tips, stats, and builds on how to beat Zilean as Cassiopeia are shown for every ranked division. If you want to scope the statistics and builds to a distinct player tier, you may use the selection menu above.