Cassiopeia is great at harassing and zoning enemies so make sure your enemy laner cannot last hit minions.
Maximize damage from Twin Fang by using it on stationary neutral monsters or stunned targets.
League of Legends Cassiopeia players may find her to be a complex champ to build out properly. You'll find that her build varies when she is fighting either well-rounded or specialized team comps, meaning you shouldn't choose the same Cassiopeia build every single round of League of Legends
The best items to incorporate into your champion's build are: Rod of Ages, Seraph's Embrace, and Cosmic Drive. Players who included these items in their builds had a much better win rate than players who tried for other item builds for Cassiopeia. Similarly, if you are playing a varied enemy team composition, you should strongly consider getting Cassiopeia the Precision, and Resolve runes. In recent games, she won the greatest number of her games when built with these runes.
We established our Cassiopeia build recommendations by analyzing 24,784 recently ranked League of Legends matches with her in them. We only advise the highest winrate Cassiopeia builds that were used by ranked LoL players enough times for us to suggest them. With so many matches in our data, we are quite confident in our recommended builds.