Cassiopeia Build

The Best Runes, Items, and Advice to Dominate Your Competition

LoL Champion


27,787 LoL Matches Analyzed

Stats Build Counters


Our Cassiopeia builds come from our evaluation of 27,787 recently ranked Cassiopeia rounds. Only the highest win rate Cassiopeia builds that are also commonly used are recommended. Because we have so many games in our database, we are absolutelysure that we can give you the highest quality builds to help ensure you win your next round!

If you are looking for more champion specific build tips and tactics, please take a look at our guide to playing with Cassiopeia farther down on the page. Additionally, to see the top Cassiopeia build from a different skill level, you can choose a different one from the dropdown menu above. The recommended Cassiopeia builds will update to capture that division’s meta.

Best Cassiopeia Runes

If you are trying to beat a mixed enemy team composition, you should strongly consider getting yourself the Conqueror, Presence of Mind, Legend: Tenacity, Coup de Grace, Taste of Blood, and Eyeball Collection runes. In recent games, she won the largest fraction of her games when using these runes. Yet, if you are facing a more homogenous enemy team composition, such as an AP heavy or a tank heavy team, you should instead glance further down to view the best Cassiopeia runes to defeat your particular enemy team.


Conqueror Rune Conqueror
Presence of Mind Rune Presence of Mind
Legend: Tenacity Rune Legend: Tenacity
Coup de Grace Rune Coup de Grace
Taste of Blood Rune Taste of Blood
Eyeball Collection Rune Eyeball Collection
Versus Selected Team Comp
Phase Rush Rune Phase Rush
Manaflow Band Rune Manaflow Band
Transcendence Rune Transcendence
Waterwalking Rune Waterwalking
Taste of Blood Rune Taste of Blood
Ravenous Hunter Rune Ravenous Hunter

Best Items for Your Cassiopeia Build

The best items to incorporate into your Cassiopeia build include: Liandry's Anguish, Rylai's Crystal Scepter, Void Staff, and Cosmic Drive. Additionally, like our rune suggestions, you can also find quality, focused, Cassiopeia item builds further down for the specific enemy team comp you are battling in your current match. Those who included these pieces in their setups had a much higher winrate than players who went for other builds for Cassiopeia.

LoL Item Liandry's AnguishLoL Item Rylai's Crystal ScepterLoL Item Void StaffLoL Item Cosmic Drive

vs AD Heavy Teams

LoL Item Liandry's AnguishLoL Item Seraph's EmbraceLoL Item Cosmic DriveLoL Item Demonic Embrace

vs AP Heavy Teams

LoL Item Liandry's AnguishLoL Item Banshee's VeilLoL Item Rylai's Crystal ScepterLoL Item Demonic Embrace

vs CC Heavy Teams

LoL Item Liandry's AnguishLoL Item Seraph's EmbraceLoL Item Rabadon's DeathcapLoL Item Void Staff

vs Tanky Teams

LoL Item Liandry's AnguishLoL Item Rylai's Crystal ScepterLoL Item Zhonya's HourglassLoL Item Cosmic Drive

Guide to Playing with Cassiopeia

  • Cassiopeia is great at harassing and zoning enemies so make sure your enemy laner cannot last hit minions.
  • Maximize damage from Twin Fang by using it on stationary neutral monsters or stunned targets.