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How to Synergize Cassiopeia with Karthus on the Same TeamCassiopeia is in the s tier of champions

Cassiopeia with Karthus

How to Win With Cassiopeia and Karthus Paired TogetherCassiopeia is in the b tier of champions
Mage
Mage

How to Synergize Cassiopeia and Karthus

based on 314 Cassiopeia with Karthus pairs
Win Rate
47.1 %
K/D/A
1.97
Pick Rate
0.9 %

How We Analyze Champion Pairings in LoL

Our servers pull the stats from from millions of League of Legends games straight from Riot Games each week. Cassiopeia has been on the same team as Karthus in 314 recent, competitive games. By amassing so much relevant data directly from the hosts of League, we have complete confidence that we can give you robust, accurate builds to help Cassiopeia play with Karthus. It is very rare for Cassiopeia to play with Karthus as teammates. This has only taken place in about 0.9% of rounds with Cassiopeia.

Cassiopeia Karthus Synergy Summary

Unfortunately, Cassiopeia does a poor job of synergizing with Karthus. Typically, she wins a lowly 47.1% of rounds the champions play on the same team. If you want to maximize your potential as Cassiopeia when fighting on the same team as Karthus by learning how to better synergize your gameplay with him, then dig into the complete build (with items, runes, summoner spells, and skills) below!

Best Cassiopeia vs Karthus Counter Build

Items

Starter Items

Time Target
Health PotionTear of the Goddess

Early Items

~5 Mins
Sapphire CrystalRuby Crystal

Core Cassiopeia Items

~22 Mins
Seraph's EmbraceLiandry's TormentRod of Ages

Optional Items

Rylai's Crystal Scepter

Summoner Spells

summonerflash summoner spell D
summonerteleport summoner spell F

Skill Order

First skill for Cassiopeia to level upe
>
Second ability for Cassiopeia to level upq
>
Last skill for Cassiopeia to max outw

Runes

PrecisionConquerorPresence of MindLegend: TenacityLast Stand
SorceryManaflow BandTranscendence
Adaptive ForceAdaptive ForceMagic Resist
Cassiopeia's passive ability p
Cassiopeia's q ability q
Cassiopeia's w ability w
Cassiopeia's e ability e
Cassiopeia's ultimate ability r
1
E
2
Q
3
W
4
E
5
E
6
R
7
E
8
Q
9
E
10
Q
11
R
12
Q
13
Q
14
W
15
W
16
R

Guide to Synergizing Cassiopeia and Karthus

Tips for Playing as Cassiopeia with Karthus

Lead your enemy when targeting with Noxious Blast to ensure the hit.

Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.

Advice to Understand How Karthus Will Play

Lay Waste is very strong at farming minions and harassing enemy champions.

Ask your allies to help point out when you should use Requiem to get kills in different lanes.

Cassiopeia Karthus Synergy Stats

Cassiopeia Image
Win Rate
47.1 %
VS
Win Rate
52.9 %
Karthus Image
6.6
< Kills >
6.8
6.6
< Deaths >
6.2
6.4
< Assists >
6.2
1.49
< Killing Sprees >
1.58
177
< Minions Killed >
175
0.18
< Dragons Killed >
0.13
0.42
< Inhibitors >
0.43
670
< Physical Damage >
639
21,936
< Magic Damage >
22,317
379
< True Damage >
342
22,985
< Damage Dealt >
23,299
28,812
< Damage Taken >
27,133
11,823
< Gold Earned >
11,743
1.67
< Towers >
1.86
0.05
< Baron Takedowns >
0.05
7,293
< Total Healing >
7,164
15,724
< Experience >
15,283
19
< Vision Score >
18
10
< Wards Placed >
9
470
< Time Dealing CC >
451

How to Play with Karthus as Cassiopeia in LoL

The Cassiopeia Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.

Overall, Cassiopeia sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA decreased from NaN to NaN. This worsening shows that Karthus helps Cassiopeia perform worse in competitive League of Legends games. Yet, the small difference indicates that this performance change is only marginal.

When Cassiopeia tries to synergize with Karthus, she gets a little drop in her total damage output. This difference could signal that Karthus doesn't help cover for her to deal more damage or that his participation also helps increase the match's duration. Similarly, when Cassiopeia is played with Karthus on the same team, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing with Karthus.

Moreover, when Cassiopeia plays with Karthus on the same side, she typically takes more damage than when she plays alone. Taking more damage may mean that Karthus does a poor job of protecting Cassiopeia in team fights.

Synergies between Cassiopeia and Karthus

Damage Types Compared

Cassiopeia
Karthus
Physical Damage
Magic Damage
True Damage

Champion Playstyles Contrasted

Cassiopeia
Karthus

Is Cassiopeia better when played alongside Karthus?

There is no one best companion for Cassiopeia that will 100% of the time be her ideal synergy. Yet, Karthus is a very bad teammate for Cassiopeia. By locking into the same team as Cassiopeia, he decreases their win rate by -3.2% to 47.1%. This shows that there is an easy to overcome and exploit bond between Cassiopeia and Karthus that allows them to perform worse together than without each other.

Karthus has a much lower diffuclty than Cassiopeia. That means Cassiopeia players don't need to be careful when arranging Karthus allies to go into battle on the same side as, as they will have to have a much lower level of skill to be able to cooperate well with you.

Fighting on the same side, you should expect to observe an overall large increase in your team’s capability to deal magic damage. Together, these champs are able to dish out a surprising amount of magic type damage.

Conversely, by grouping Cassiopeia and Karthus together, you probably will not be providing your other teammates a lot of AD. Plan to include other champs on your team that nullifies this relative hole in this pairing's abilities.

Regardless of your Karthus ally's skill level, you should focus on maximizing your gold income, staying alive by avoiding foolish fights, and taking down objectives. If you heed this simple advice, you should do well anyway.

Additional Information for Cassiopeia Players

How We Calculated Our Cassiopeia Karthus Synergy Build and Stats

For this guide on pairing Cassiopeia and Karthus, we analyzed 314 ranked and recent League of Legends matches. We perform advanced data cleaning and statistical methods to guarantee that our team synergy stats are accurate and reliable. You can be confident that our recommended build to pair Cassiopeia with Karthus comes from actual data and is not the fabrication of some random LoL player, as some other sites provide. You can use the filters at the top of the page to view your division's most relevant stats and build.

Other Useful Resources

Further Insights to Win with this Champion Pairing

To truly master Cassiopeia to work well with Karthus during both the laning and mid / late game phases of League rounds, you should continue reading to gather some more lessons on this champion pairing. If you mind the build and tips displayed above, you will grow your win rate by a lot.

The top finished items to build first in your Cassiopeia and Karthus synergy build include Seraph's Embrace, Liandry's Torment, and Rod of Ages. When Cassiopeia incorporated at least these three items in her build, she did much better when paired up with Karthus than with most other common item sets. In fact, Cassiopeia had an average winrate of 47.1% when playing alongside Karthus with these items in her kit.

To have the highest probability of crushing your oponents, you should equip the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Manaflow Band, and Transcendence runes from the Precision and Sorcery rune sets. Of all the rune builds players chose for this team composition, this sequence of runes resulted in the top win rate. Notably, these runes averaged a 47.1% win rate overall.

By default, tips, statistics, and builds on how to synergize Karthus with Cassiopeia are presented for all skill levels combined. To filter the statistics and builds to a distinct division, you should use the selection menu located earlier in the counter matchup guide.