Background Image
How to Synergize Karthus with Cassiopeia on the Same TeamKarthus is in the b tier of champions

Karthus with Cassiopeia

How to Win With Karthus and Cassiopeia Paired TogetherKarthus is in the s tier of champions
Mage
Mage

How to Synergize Karthus and Cassiopeia

based on 314 Karthus with Cassiopeia pairs
Win Rate
47.1 %
K/D/A
2.11
Pick Rate
0.6 %

How We Analyze Champion Pairings in LoL

At MOBA Champion, we take in the results of from millions of League games straight from Riot Games each and every week. Karthus has gone into battle with Cassiopeia in 314 recently played, competitive games. By gathering so much complete data from the creators of League, we have complete confidence that we can showcase high-quality, usable builds to help Karthus play with Cassiopeia. It is very rare for Karthus to play alongside Cassiopeia as allies. This has only taken place in approximately 0.6% of matches with Karthus.

Karthus Cassiopeia Synergy Summary

Unfortunately, Karthus has done a below average job of fighting on the same side as Cassiopeia. Normally, he wins a lowly 47.1% of matches the champs appear on the same team. If you want to win more matches as Karthus when playing with Cassiopeia by figuring out how to better synergize your strategy with her, then review the complete build (with items, runes, summoner spells, and skills) below!

Best Karthus vs Cassiopeia Counter Build

Items

Starter Items

Time Target
Scorchclaw PupHealth Potion

Early Items

~5 Mins
Amplifying TomeGlowing Mote

Core Karthus Items

~22 Mins
MalignanceShadowflameLiandry's Torment

Optional Items

Rabadon's DeathcapStormsurge

Summoner Spells

summonerexhaust summoner spell D
summonersmite summoner spell F

Skill Order

First skill for Karthus to level upq
>
Second ability for Karthus to level upe
>
Last skill for Karthus to max outw

Runes

InspirationFirst StrikeMagical FootwearFuture's MarketCosmic Insight
DominationEyeball CollectionUltimate Hunter
Adaptive ForceAdaptive ForceArmor
Karthus's passive ability p
Karthus's q ability q
Karthus's w ability w
Karthus's e ability e
Karthus's ultimate ability r
1
Q
2
E
3
Q
4
W
5
Q
6
R
7
Q
8
E
9
Q
10
E
11
R
12
E
13
E
14
W
15
W
16
R

Guide to Synergizing Karthus and Cassiopeia

Tips for Playing as Karthus with Cassiopeia

Lay Waste is very strong at farming minions and harassing enemy champions.

Ask your allies to help point out when you should use Requiem to get kills in different lanes.

Advice to Understand How Cassiopeia Will Play

Lead your enemy when targeting with Noxious Blast to ensure the hit.

Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.

Karthus Cassiopeia Synergy Stats

Karthus Image
Win Rate
47.1 %
VS
Win Rate
52.9 %
Cassiopeia Image
7.1
< Kills >
7
7.9
< Deaths >
7.6
9.6
< Assists >
9.5
1.7
< Killing Sprees >
1.63
78
< Minions Killed >
88
0.97
< Dragons Killed >
0.89
0.25
< Inhibitors >
0.28
244
< Physical Damage >
246
29,223
< Magic Damage >
29,153
2,064
< True Damage >
2,031
31,532
< Damage Dealt >
31,430
31,347
< Damage Taken >
29,785
13,004
< Gold Earned >
12,799
1.01
< Towers >
1.08
0.25
< Baron Takedowns >
0.23
10,187
< Total Healing >
9,279
14,971
< Experience >
14,921
19
< Vision Score >
19
7
< Wards Placed >
7
227
< Time Dealing CC >
221

How to Play with Cassiopeia as Karthus in LoL

The Karthus Cassiopeia synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Cassiopeia, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.

Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Cassiopeia. His KDA went down from NaN to NaN. This decrease shows that Cassiopeia helps Karthus perform worse in competitive League games. Yet, the small difference shows that this performance change is only marginal.

When Karthus tries to synergize with Cassiopeia, he observes a little increase in his total damage dealt. This difference could signal that Cassiopeia supports by providing cover for him to dish out more damage or that her allyship also helps extend the match's duration. Similarly, when Karthus is played with Cassiopeia on the same side, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing synergisticly with Cassiopeia.

Additionally, when Karthus plays with Cassiopeia on the same side, he often receives more damage than when he plays alone. Receiving more damage may indicate that Cassiopeia does a poor job of covering Karthus during team fights.

Synergies between Karthus and Cassiopeia

Damage Types Compared

Karthus
Cassiopeia
Physical Damage
Magic Damage
True Damage

Champion Playstyles Contrasted

Karthus
Cassiopeia

Is Karthus better when played alongside Cassiopeia?

There is no universally accepted best ally for Karthus that will always be his top teammate. However, Cassiopeia is a very typical companion for Karthus. By playing on the same team as Karthus, she drops their win rate by -0.2% to 47.1%. This signals that there is only a small bond between Karthus and Cassiopeia that allows them to perform worse together than without each other.

Cassiopeia has a greater difficulty than Karthus. That means Karthus players should be cautious when enlisting Cassiopeia comrades to go into battle on the same side as, as they will need a greater level of skill to be able to work well with you.

Playing together, Karthus players should see an overall large increase in your team’s capacity to deal magical damage. Combined, these two are able to dish out a surprising amount of magic type damage.

Conversely, by grouping Karthus and Cassiopeia together, you may not be granting your team very much sustained damage output. Plan to pick other champions on your team that fills this hole in their playstyle.

Regardless of your Cassiopeia ally's ability, you need to focus on maximizing your gold income, warding to avoid ambushes, and clearing objectives. If you follow these simple suggestions, you should do well, regardless.

Additional Information for Karthus Players

How We Calculated Our Karthus Cassiopeia Synergy Build and Stats

For this guide on pairing Karthus and Cassiopeia, we analyzed 314 ranked and recent League of Legends matches. We perform advanced data cleaning and statistical methods to guarantee that our team synergy stats are accurate and reliable. You can be confident that our recommended build to pair Karthus with Cassiopeia comes from actual data and is not the fabrication of some random LoL player, as some other sites provide. You can use the filters at the top of the page to view your division's most relevant stats and build.

Other Useful Resources

Further Insights to Win with this Champion Pairing

If you would like to learn all of the intricacies of Karthus in order to pair well with Cassiopeia during both the early game and mid / late game phases of LoL rounds, you should keep reading to master some more lessons on this champion pairing. If you listen to the build and tips shown above, you will increase your win rate by a lot.

The most crucial items to include in your Karthus and Cassiopeia synergy build include Malignance, Shadowflame, and Liandry's Torment. When Karthus combined at least these three great items in his build, he did significantly better as an ally of Cassiopeia than with many other typical item sets. In fact, Karthus had an average winrate of 47.1% when synergizing his build and playstyle to Cassiopeia with this build.

To have the best chance of defeating your oponents, you should take the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the rune sets we have analyed for this champion pairing, this combo of runes resulted in the best win rate. Moreover, these runes averaged a 47.1% win rate overall.

If you need to view Karthus with Cassiopeia synergy tips and builds for a a distinct division, feel free to select one from the selection menu shown above. If viewing for the first time, the stats and tips and suggestions displayed are calculated using all rounds run with these champions.