Karthus vs Lissandra Counter Build

How to Beat Lissandra as Karthus


We produce our matchup stats from the millions of recently rated League matches that we evaluate each week. This Karthus vs Lissandra counter review came out of an evaluation of 1,099 ranked games where both champs faced off against one another.

This counter matchup is somewhat rare. Karthus fights Lissandra in only 0.9% of his rounds. Karthus does a good job of countering Lissandra. On average, he wins a fantastic 53.0% of the time the champions oppose one another in. In Karthus versus Lissandra matches, Karthus’s side is 3.0% less probable to obtain first blood, implying that he probably won't get first blood versus Lissandra.

Matchups Analyzed


Win Rate


Team First Blood


Best Karthus Items to Counter Lissandra

The best items to focus on in your Karthus versus Lissandra build include Rabadon's Deathcap, Morellonomicon, and Liandry's Anguish. When Karthus used at least these three pieces in his build, he did significantly better against Lissandra than with most other common builds.

Rabadon's Deathcap Item Morellonomicon Item Liandry's Anguish Item

Best Karthus Runes to Counter Lissandra

To have the highest probability of annihilating Lissandra as Karthus, Karthus players should take the Dark Harvest, Taste of Blood, Eyeball Collection, Ravenous Hunter, Presence of Mind, and Coup de Grace runes. Of all the rune sets players used for Karthus vs Lissandra clashes, this mix of runes resulted in the highest win rate. We have also shown the top Lissandra runes to counterpick against Karthus to help you recognize how she will likely be built against your champ.

Best Karthus Runes

Dark Harvest Rune Dark Harvest
Taste of Blood Rune Taste of Blood
Eyeball Collection Rune Eyeball Collection
Ravenous Hunter Rune Ravenous Hunter
Presence of Mind Rune Presence of Mind
Coup de Grace Rune Coup de Grace

Best Lissandra Runes

Electrocute Rune Electrocute
Cheap Shot Rune Cheap Shot
Eyeball Collection Rune Eyeball Collection
Ultimate Hunter Rune Ultimate Hunter
Transcendence Rune Transcendence
Manaflow Band Rune Manaflow Band


The subsequent tables emphasize several vital Karthus versus Lissandra counter stats that can help us explain the distinctions between the pair. For instance, Karthus’s KDA ratio ([kills + assists] / deaths) of 2.4 is close to Lissandra’s ratio of 2.1, demonstrating that Karthus may be just as central to his team's team fighting capability than Lissandra.

Battle Stats


Karthus Stats
8.2 6
Lissandra Stats


Karthus Stats
7.4 6.9
Lissandra Stats


Karthus Stats
9.6 8.8
Lissandra Stats

Largest Killing Spree

Karthus Stats
3 2.5
Lissandra Stats

Damage Dealt

Karthus Stats
28857 18631
Lissandra Stats

Damage Taken

Karthus Stats
24952 21212
Lissandra Stats

Objective Stats

Towers Destroyed

Karthus Stats
5.5 5.2
Lissandra Stats

Inhibitors Destroyed

Karthus Stats
0.9 0.9
Lissandra Stats

Dragons Killed

Karthus Stats
2 2.1
Lissandra Stats

Barons Killed

Karthus Stats
0.4 0.4
Lissandra Stats

Gold Earned

Karthus Stats
12213 10779
Lissandra Stats

Minions Killed

Karthus Stats
88 145
Lissandra Stats

Karthus normally has a slightly larger longest kill spree than his foe does. On average, Karthus takes more damage than Lissandra. This commonly reflects differing health capacities, but it can also hint that the champion with increased HP has less mobility and thus is unable to flee from additional damage when poked or engaged.

Karthus usually totals much less CS than Lissandra. Champs that don't earn a lot of minion kills typically don't need much CS to be useful. Instead, they are able to scale easily off of their skills and stats alone. Yet, champions with large amounts of CS, such as carries, typically have to have a lot of gold to be useful. In either situation, try to outperform the averages displayed here to do well.

By default, Karthus vs Lissandra tips, stats, and build recommendations are displayed for all skill levels combined. If you would like to scope the statistics and builds to a particular player tier, you can use the selection menu located at the top of the page.

How We Analyze Our Matchups

For this counter guide, we analyzed 1099 Karthus vs Lissandra matchups from recent LoL games. We use rigorous data cleaning and processing methods to ensure that our counter stats are of the highest quality. You can rest assured that the recommended build to counter Lissandra as Karthus comes from real data and is not the fabrication of some random LoL player, as some other sites provide. You can use the filters at the top of the page to view the most relevant stats and items to your rank.