Try to coordinate high-damage abilities with your allies right after Dr. Mundo uses his ultimate, but if you're unable to kill him quickly with burst he will heal through the damage.
Try casting Ignite when Dr. Mundo uses Sadism to negate a large portion of its healing.
The stat comparisons provided here show some strategic Senna vs. Dr. Mundo matchup stats that can help us realize the distinctions between the pair. As an example, Senna’s KDA ratio ([kills + assists] / deaths) of NaN is more than Dr. Mundo’s ratio of NaN, demonstrating that Senna may be more central to her team's team fighting capacity than Dr. Mundo. This observation is largely fueled by the differences in assists.
Senna typically has a similar longest killing spree as her enemy does. On average, she takes less damage than Dr. Mundo. This is usually reflective of different amounts of tankyness; however, it can also hint that the champion with higher health has less mobility and thus is unable to escape additional harm when engaged or poked.
Both League champions are great champions. Both have their pros and cons. In League's current meta, Senna usually loses when playing against Dr. Mundo, with a 47.8% win rate. Thus, Senna makes a bad counter to Dr. Mundo.
While Senna does have a lower winrate compared to Dr. Mundo, when they face off with one another, Senna also has a greater difficulty level that makes her a more difficult champion to pick up and master. You may get destroyed when picking Senna into Dr. Mundoas her relative depth means you may not be able to reach her full potential without a significant amount of practice beforehand.
Furthermore, Senna also has a good amount of CC and other utility, a similar amount to Dr. Mundo. This makes her just as valuable during teamfights, especially when trying to counter champions with a ton of burst damage.
While there is not one best champion overall in League of Legends, in Senna vs Dr. Mundo matchups, Dr. Mundo is the better champ with a lower win rate, more champion depth, and a similar amount of utility to help out your allied champions during late stage team fights.
Senna is a terribly counter for Dr. Mundo. You will do well by focussing your gameplay on maximizing your CS and clearing objectives. If you can do that, you should do very well as Senna against Dr. Mundo.
If you would like to truly master Senna to counter Dr. Mundo during both the laning and mid / late game phases of League of Legends, you should keep reading to gather a few extra tricks and insights into this matchup. If you mind the build and stats shown here, you should increase your win rate significantly and be that much closer to League of Legends pro players.
Senna usually picks up a lot less CS relative to Dr. Mundo. Champs who typically don't get much CS typically don't need much CS to be effective, such as supports. They are able to scale properly off of their skills, stats, and first items alone. Yet, champions with a lot of CS, such as hyper-carries, often have to have a lot of items to be effective. In either situation, try to exceed the numbers displayed here to do well.
The most crucial items to prioritize in your Senna versus Dr. Mundo build include Eclipse, Lord Dominik's Regards, and Black Mist Scythe. When Senna bought at least these three items in her build, she performed a lot better against Dr. Mundo than with most other common item sets. In fact, Senna boasted an average winrate of 47.8% when playing against Dr. Mundo with these items in her kit.
To have the greatest likelihood of vanquishing Dr. Mundo as Senna, Senna players should use the Fleet Footwork, Presence of Mind, Legend: Alacrity, Cut Down, Biscuit Delivery, and Approach Velocity runes from the Precision and Inspiration rune sets. Out of all the rune builds we have analyed for Senna vs Dr. Mundo battles, this combination of runes yielded the best win rate. Moreover, these runes averaged a 47.8% winrate overall.
By default, tips, statistics, and builds on how to beat Dr. Mundo as Senna are given for all skill levels, merged. If you want to narrow the stats and builds to a specific division, you may use the selection menu located earlier in the counter matchup guide.