LoL Senna players could find her to be a confusing character to build out properly. You will notice that her build varies when she is fighting either well-rounded or homogenous team comps, showing you shouldn't choose the same Senna build every single game of League of Legends
The best items to include in your champ's build are: Eclipse, Manamune, and Umbral Glaive. Players who included these pieces in their setups had a better win rate than those who utilized other item builds for Senna. Likewise, if you are facing a varied enemy team comp, you should really consider grabbing her the Precision, and Sorcery runes. In recent matches, she won the largest number of her rounds when equipped with these runes.
We established our Senna build guidance by analyzing 103,381 recently ranked League rounds with her selected. We only propose the top winrate Senna builds that were built by ranked League players enough times for us to advise them. With so many matches in our dataset, we are quite confident in our provided builds.