Try to take Vladimir down before Hemoplague detonates, as it will heal him for each afflicted enemy Champion.
Making Vladimir use Sanguine Pool at the start of a fight will maximize the Health cost of the ability to him.
Items that counter Health stacking, such as Liandry's Torment and Blade of the Ruined King, are very effective against Vladimir.
The stat comparisons shown here clarify several significant Sett vs. Vladimir counter statistics that can help us explain the differences and similarities between the two. Sett’s KDA ratio ([kills + assists] / deaths) of NaN is more than Vladimir’s KDA ratio of NaN, indicating that Sett may be more central to his team's team fighting capability than Vladimir..
Sett usually has a similar longest killing spree as his enemy does. On average, he receives a similar amount of damage to Vladimir. This commonly reflects differing health capacities; however, it can also imply that the champ with more HP has less mobility and thus is not able to flee from additional damage when poked or engaged.
Both League champions are great champions. Both have their pros and cons. In League's current meta, Sett usually fairs equally well when playing against Vladimir, with a 50.0% win rate. Therefore, Sett makes an ok counter for Vladimir.
While Sett does have a higher win rate than Vladimir, when facing one another, Sett also has a much lower learning curve that makes him a less difficult character to pick up and master. You still need to be cautious when picking Sett into Vladimir.
Moreover, Sett also has almost no amount of CC and other utility, a similar amount to Vladimir. This makes her just as valuable during team fights, especially when facing champions with a lot of burst damage.
While there is not one best champion overall in League of Legends, in Sett vs Vladimir matchups, Vladimir is the better champion with a similar win rate, less champion complexity, and a similar amount of utility to help out your team members during team fights.
Sett is a decent counter to Vladimir. Make sure you focus your tactics on maximizing your gold and cs and clearing objectives. If you are able to do that, you should do very well as Sett against Vladimir.
If you would like to learn all of the intricacies of Sett in order to counter Vladimir during both the laning and mid / late game phases of League of Legends, you should keep reading to pick up a few extra lessons on this matchup. If you listen to the build and stats presented above, you will grow your win rate significantly and be closer to League of Legends pro players.
Sett typically picks up a similar amount of CS as Vladimir. Champions who typically don't get much CS typically don't have to have much CS to be valuable teammates, such as sup champs. These kinds of champions are able to scale well off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, typically have to have many items to be effective. In either situation, try to surpass the values reported here to do well.
The ideal items to focus on in your Sett versus Vladimir build include Stridebreaker, Hullbreaker, and Titanic Hydra. When Sett used at least these three pieces in his build, he did significantly better vs. Vladimir than with many other common item sets. In fact, Sett boasted an average winrate of 50.0% when countering Vladimir with these items in his kit.
To have the highest probability of beating Vladimir as Sett, you should equip the Conqueror, Triumph, Legend: Alacrity, Last Stand, Bone Plating, and Unflinching runes from the Precision and Resolve rune sets. Out of all the rune combinations players used for Sett vs Vladimir battles, this blending of runes yielded the highest win rate. In fact, these runes gave a 50.0% win rate overall.
By default, tips, stats, and builds on how to beat Vladimir as Sett are presented for all skill levels, merged. To narrow the stats and builds to a particular player tier, you can use the selection menu located above.