Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
The Cassiopeia Twitch synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Twitch, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Cassiopeia sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Twitch. His KDA decreased from NaN to NaN. This negative change shows that Twitch helps Cassiopeia perform worse in ranked LoL rounds. Yet, the small difference shows that this performance change is not very impactful.
When Cassiopeia tries to synergize with Twitch, she gets a little increase in her total damage dealt. This difference could signal that Twitch supports by providing cover for her to deal more damage or that his participation also helps increase the game's duration. Similarly, when Cassiopeia is played with Twitch on the same side, he usually scores many fewer killing sprees than when she plays without Twitch. This is contrasting evidence that she is worse when playing alongside Twitch.
Additionally, when Cassiopeia plays with Twitch on the same side, she typically receives a little less damage than when she fights alone. Receiving not as much damage could indicate that Twitch does a decent job of protecting Cassiopeia during team fights.
There is no universally accepted best companion for Cassiopeia that will 100% of the time be her top ally. However, Twitch is a decent companion for Cassiopeia. By playing on the same side as Cassiopeia, he raises their win rate by 2.9% to 54.0%. This demonstrates that there is a good synergy between Cassiopeia and Twitch that results in them performing at the top of their game together than without each other.
Twitch has a much lower diffuclty than Cassiopeia. That means you don't need to be very careful when enlisting Twitch teammates to play with, as they will need a much lower level of skill to be able to work well with you.
Working alongside, you will likely witness an overall large increase in your team’s ability to deal magical damage. Together, these champs are able to dish out a surprising amount of magic type damage.
Conversely, by grouping Cassiopeia and Twitch together, you will not be granting your side much tankyness. Make sure to include other champs on your team that helps cover this disparity in this pairing's abilities.
Regardless of the skill of your Twitch teammate, you should focus on increasing your gold income, warding to avoid ambushes, and clearing objectives. If you do this, you should do well, regardless.
If you would like to learn all of the intricacies of Cassiopeia in order to work well with Twitch during both the lane and mid / late game phases of League rounds, you should keep reading to learn additional tips and tricks for this champion pairing. If you mind the build and stats shown here, you will grow your win rate significantly.
The most important items to include in your Cassiopeia and Twitch synergy build consist of Liandry's Anguish, Seraph's Embrace, and Rabadon's Deathcap. When Cassiopeia combined at least these three finished items in her build, she did a lot better as an ally of Twitch than with many other common builds. In fact, Cassiopeia boasted an average win rate of 54.0% helping carry Twitch with this build.
To have the best likelihood of vanquishing your oponents, Cassiopeia players should equip the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Of all the rune sets that we analyzed for this team composition, this composite of runes yielded the top win rate. In fact, these runes averaged a 54.0% win rate overall.
By default, tips, statistics, and builds on how to synergize Twitch with Cassiopeia are displayed for all ranked divisions. If you would like to scope the statistics and builds to a particular rank, you should use the selection menu earlier on the page.