Use Overload's passive to optimize for maximum damage or maximum speed.
Ryze can move and cast other spells while Realm Warp is charging without cancelling the portal.
Spell Flux's short cooldown allows it to be used to spread Flux to many enemies.
Sanguine Pool pops incoming missiles, so it can be used to dodge disables.
Transfusion instantly deals damage to the enemy before healing Vladimir, making it one of the best last hitting tools in the game.
Cast Hemoplague where it will afflict the most units.
The Ryze Vladimir synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Vladimir, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Ryze sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Vladimir. His KDA fell from NaN to NaN. This fall shows that Vladimir helps Ryze perform worse in competitive LoL games. Yet, the small difference demonstrates that this performance change is only marginal.
When Ryze is an ally to Vladimir, he gets a measurable drop in his full damage dealt. This change may signal that Vladimir does not support by providing protection for him to deal more damage or that his participation also helps increase the game's duration. Similarly, when Ryze is played alongside Vladimir on the same team, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing with Vladimir.
Moreover, when Ryze plays with Vladimir on the same side, he usually takes less damage than when he fights alone. Receiving not as much damage may mean that Vladimir does a decent job of protecting Ryze during team fights.
There is no ideal synergy for Ryze that will always be his ideal teammate. However, Vladimir is a great teammate for Ryze. By being on the same side as Ryze, he improves their win rate by 8.2% to 57.9%. This clearly indicates that there is a very real strategic relationship between Ryze and Vladimir that results in them performing at the top of their game together than without each other.
Vladimir has a lower difficulty than Ryze. That means you don't need to be cautious when finding Vladimir teammates to fight alongside, as they will have to have a relatively low level of skill to be able to cooperate well with you.
Working together, you should witness an overall large increase in your team’s capacity to deal magical damage. Combined, these champions can blast through enemies with magic damage.
In contrast, by bringing Ryze and Vladimir together, you may not be granting your team much sustained damage output. Plan to bring other champs on your team that neutralizes this disparity in this pairing's capabilities.
Regardless of your Vladimir ally's ability, you need to focus on maximizing your income, outlasting your enemies, and clearing objectives. If you follow these simple suggestions, you will do well anyway.
If you would like to learn all of the intricacies of Ryze to work well with Vladimir during both the laning and mid / late game phases of League of Legends, you should continue reading to pick up some more lessons on this champion pairing. If you pay attention to the build and suggestions displayed above, you will increase your win rate by a lot.
The top finished items to include in your Ryze and Vladimir synergy build include Rod of Ages, Seraph's Embrace, and Rabadon's Deathcap. When Ryze incorporated at least these three finished items in his build, he did significantly better as an ally of Vladimir than with most other common item sets. In fact, Ryze had an average winrate of 57.9% when playing alongside Vladimir with these items in his kit.
To have the highest probability of coming out on top against your oponents, you should equip the Phase Rush, Manaflow Band, Transcendence, Gathering Storm, Bone Plating, and Overgrowth runes from the Sorcery and Resolve rune sets. Of all the rune combinations players used for Ryze and Vladimir pairings, this sequence of runes resulted in the best win rate. Moreover, these runes averaged a 57.9% winrate overall.
By default, tips, statistics, and builds on how to team up Vladimir with Ryze are presented for every ranked division. To narrow the stats and builds to a particular rank, you should use the selection menu located earlier in the counter matchup guide.