Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
You can catch up to an enemy out of attack range with Venom Cask.
Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Storing a stun for use with her ultimate can turn the tide of a team fight.
The Twitch Annie synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Annie, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Annie. His KDA decreased from NaN to NaN. This drop shows that Annie helps Twitch perform not as well in ranked League of Legends matches. Yet, the small difference shows that this performance change is not very impactful.
When Twitch tries to synergize with Annie, he sees a marginal improvement in his full damage output. This change may demonstrate that Annie helps provide protection for him to deal more damage or that her presence on the team also helps extend the round's duration. Similarly, when Twitch is played alongside Annie on the same team, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing synergisticly with Annie.
Moreover, when Twitch plays with Annie on the same side, he usually takes a little more damage than when he fights alone. Taking more damage may mean that Annie does a poor job of protecting Twitch during team fights.
There is no one best champion pairing for Twitch that will no matter what be his ideal ally. Yet, Annie is a very typical companion for Twitch. By playing on the same side as Twitch, she drops their win rate by -0.3% to 50.2%. This signals that there is a weak strategic relationship between Twitch and Annie that allows them to perform worse together than alone.
Annie has a lower difficulty than Twitch. That means Twitch players don't need to be careful when arranging Annie allies to fight alongside, as they will need a relatively low level of skill to play well with you.
Playing on the same side, Twitch players will likely observe an overall large increase in your team’s capacity to deal magical damage. Together, these two can deal quite a lot of AP type damage.
Although, by pairing Twitch and Annie together, you will not be granting your side a lot of engage. Plan to include other champions on your team that offsets this relative hole in their abilities.
Regardless of your Annie ally's skill level, you should focus on maximizing your gold income, outlasting your enemies, and taking down objectives. If you heed this simple advice, you will do well, regardless.
If you would like to truly master Twitch to synergize with Annie during both the early game and mid / late game phases of League of Legends rounds, you should continue reading to learn a few extra lessons on this champion pairing. If you pay attention to the build and tips presented above, you should grow your win rate by a lot.
The best finished items to prioritize in your Twitch and Annie synergy build include Guinsoo's Rageblade, Lord Dominik's Regards, and Blade of The Ruined King. When Twitch bought at least these three items in his build, he did much better as an ally of Annie than with many other common item sets. In fact, Twitch boasted an average winrate of 50.2% helping carry Annie with this build.
To have the best likelihood of vanquishing your oponents, you should equip the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Out of all the runes players chose for this champion pairing, this combo of runes yielded the greatest win rate. Moreover, these runes averaged a 50.2% win rate overall.
By default, tips, stats, and builds on how to pair Annie with Twitch are presented for every ranked division. To filter the stats and builds to an individual player tier, you should use the selection menu above.