Be very careful about when to use Life Form Disintegration Ray. Many champions have abilities that can interrupt the spell.
Shooting Plasma Fission diagonally and splitting at maximum range allows you to hit opponents that are out of the range of the initial missile, but is more challenging to pull off.
When laning, use Void Rift to kill minions while building stacks of Organic Deconstruction on your opponent. You can then follow up with your other abilities.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Vel'Koz Karthus synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Karthus, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Vel'Koz sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA decreased from NaN to NaN. This drop shows that Karthus helps Vel'Koz perform not as well in ranked League rounds. Yet, the small difference proves that this performance change is only marginal.
When Vel'Koz plays on the same team as Karthus, he gets a little drop in his total damage dealt. This difference may signal that Karthus does not provide protection for him to deal more damage or that his participation also helps increase the match's duration. Similarly, when Vel'Koz is played with Karthus on the same team, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing alongside Karthus.
Moreover, when Vel'Koz plays with Karthus on the same side, he typically takes more damage than when he fights alone. Getting dealt more damage could mean that Karthus does a poor job of protecting Vel'Koz during team fights.
There is no ideal synergy for Vel'Koz that will always be his top ally. However, overall, Karthus is a terrible ally for Vel'Koz. By being on the same side as Vel'Koz, he decreases their win rate by -4.5% to 45.8%. This signals that there is an easy to overcome and exploit bond between Vel'Koz and Karthus that results in them performing not as well together than without each other.
Karthus has a lower difficulty than Vel'Koz. That means Vel'Koz players don't need to be very careful when arranging Karthus allies to play with, as they will have to have a lower level of skill to play well with you.
Working on the same side, Vel'Koz players should observe an overall large increase in your team’s capacity to deal magic damage. Combined, these champions are able to dish out a surprising amount of magic type damage.
Although, by aligning Vel'Koz and Karthus together, you probably will not be giving your other allies very much anti-tank damage dealing potential. Plan to include other champs on your team that fills this disparity in their capabilities.
Regardless of the skill of your Karthus teammate, you should focus on maximizing your gold income, warding to avoid ambushes, and taking down objectives. If you follow these simple suggestions, you should do well, regardless.
To truly master Vel'Koz in order to synergize with Karthus during both the early game and mid / late game phases of LoL matches, you should continue reading to pick up a few extra tricks and insights into this champion pairing. If you pay attention to the build and suggestions presented here, you will grow your win rate significantly.
The best finished items to prioritize in your Vel'Koz and Karthus synergy build include Zaz'Zak's Realmspike, Shadowflame, and Stormsurge. When Vel'Koz bought at least these three finished items in his build, he performed significantly better when paired up with Karthus than with many other commonly used builds. In fact, Vel'Koz boasted an average win rate of 45.8% when synergizing his build and playstyle to Karthus with this build.
To have the best probability of defeating your oponents, you should use the Arcane Comet, Manaflow Band, Transcendence, Scorch, Biscuit Delivery, and Cosmic Insight runes from the Sorcery and Inspiration rune sets. Out of all the runes players picked for this champion pairing, this set of runes yielded the top win rate. In fact, these runes gave a 45.8% winrate overall.
If you would like to view Vel'Koz and Karthus synergy tips and stats for a an individual rank, feel free to choose one from the selection menu provided above. If viewing for the first time, the stats and build suggestions shown are computed using all rounds finished with both champs.