Don't be too conservative with Mantra. Gathering Fire is strongest in teamfights, making it easy to recharge Mantra multiple times.
When using Focused Resolve, slow your opponents with Inner Flame or speed yourself up with Inspire if you're having trouble sticking to a target.
Gathering Fire rewards aggressive play. Look to land abilities and basic attacks on your opponent to lower Mantra's cooldown and stay on the offensive.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
Deny Vayne the opportunity to pin you against walls.
The stats provided here underscore some vital Karma vs. Vayne matchup statistics that can help you figure out the differences and similarities between the two. For instance, Karma’s KDA ratio ([kills + assists] / deaths) of NaN is more than Vayne’s ratio of NaN, showing that Karma may be more central to her team's team fighting capability than Vayne. This observation is in large part caused by the differences in assists.
Karma usually has a significantly smaller longest kill spree than her foe does. Typically, she receives a similar amount of damage to Vayne. This is usually reflective of different amounts of tankyness; however, it can also hint that the one champion has less mobility and thus is unable to kite away from further damage when poked or engaged.
Both League of Legends champs are great champions. Both champs have their strengths, weaknesses, and counters. In League's current meta, Karma usually fairs equally well when facing off against Vayne, with a 49.8% win rate. Therefore, Karma makes an ok counter to Vayne.
While Karma does have a lower winrate than Vayne, when on opposite teams, Karma also has a lower level of difficulty that makes her a less challenging champ to pick up and master. You still need to be cautious when picking Karma into Vayne.
Additionally, Karma has a good amount of CC and other utility, a similar amount to Vayne. This often makes her just as valuable during team fights, especially when trying to counter champions with a ton of burst damage.
While there is not a single best champion for every situation in League of Legends, in Karma vs Vayne matchups, Vayne is the better champion with a similar win rate, less champion complexity, and a similar amount of utility to help out your allied champions during team fights.
Karma is a somewhat poor counter to Vayne. Make sure you focus your play on maximizing your gold and cs and clearing objectives. If you do that, you should be able to stand on your own as Karma against Vayne.
If you would like to learn all of the intricacies of Karma to counter Vayne during both the lane and mid / late game phases of League of Legends, you should continue reading to learn a few extra lessons on this matchup. If you pay attention to the build and stats displayed here, you should increase your win rate significantly and be that much closer to League of Legends pro players.
Karma on average accumulates a lot less CS relative to Vayne. Champions who typically don't get many minion kills usualy don't have to have much CS to be valuable teammates, such as support champions. They are capable of scaling properly off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, usually require many items to be effective. In either case, try to surpass the values reported on this page to do well.
The most crucial items to use in your Karma versus Vayne build include Luden's Tempest, Shard of True Ice, and Shadowflame. When Karma bought at least these three items in her build, she did a lot better countering Vayne than with many other common counter builds. In fact, Karma had an average winrate of 49.8% battling Vayne with these items in her kit.
To have the greatest likelihood of crushing Vayne as Karma, Karma players should equip the Summon Aery, Manaflow Band, Transcendence, Scorch, Bone Plating, and Revitalize runes from the Sorcery and Resolve rune sets. Of all the rune combinations players picked for Karma vs Vayne LoL games, this sequence of runes resulted in the highest win rate. In fact, these runes averaged a 49.8% winrate overall.
By default, tips, statistics, and builds on how to beat Vayne as Karma are displayed for all skill levels combined. If you want to scope the statistics and builds to an individual skill level, you can use the selection menu located earlier in the counter matchup guide.