Karthus vs Sett Counter Build

How to Beat Sett as Karthus


We get our counter stats from the millions of recently rated LoL games that we review each and every week. This Karthus versus Sett counter review resulted from an evaluation of 17,235 ranked rounds where both champions battled one another.

This counter matchup is somewhat common. Karthus encounters Sett in 48.2% of his matches. Unfortunitally, Karthus does a poor job of countering Sett. Normally, he wins a acceptable 49.0% of games the champs oppose one another in. In Karthus versus Sett matches, Karthus’s side is 8.0% less likely to obtain first blood, indicating that he probably won't get first blood versus Sett.

Matchups Analyzed


Team First Blood


Win Rate


Best Karthus Items to Counter Sett

The most important items to have in your Karthus versus Sett build include Rabadon's Deathcap, Demonic Embrace, and Liandry's Anguish. When Karthus incorporated at least these three pieces in his build, he performed a lot better vs Sett than with most other common builds.

Rabadon's Deathcap Item Demonic Embrace Item Liandry's Anguish Item

Best Karthus Runes to Counter Sett

To have the best probability of vanquishing Sett as Karthus, you should use the Dark Harvest, Taste of Blood, Eyeball Collection, Ravenous Hunter, Presence of Mind, and Last Stand runes. Out of all the rune sets that we analyzed for Karthus vs Sett matchups, this composite of runes resulted in the best win rate. We have also included the top Sett runes to fend off Karthus in order to help you infer how he will probably be built against your champ.

Best Karthus Runes

Dark Harvest Rune Dark Harvest
Taste of Blood Rune Taste of Blood
Eyeball Collection Rune Eyeball Collection
Ravenous Hunter Rune Ravenous Hunter
Presence of Mind Rune Presence of Mind
Last Stand Rune Last Stand

Best Sett Runes

Conqueror Rune Conqueror
Triumph Rune Triumph
Legend: Tenacity Rune Legend: Tenacity
Last Stand Rune Last Stand
Bone Plating Rune Bone Plating
Revitalize Rune Revitalize


The following tables highlight several important Karthus vs. Sett counter statistics that can help you interpret the differences and similarities between this pair of champions. Karthus’s KDA ratio ([kills + assists] / deaths) of 2.3 is more than Sett’s ratio of 2.0, demonstrating that Karthus may be more central to his team's team fighting potential than Sett.

Battle Stats


Karthus Stats
7.5 6.2
Sett Stats


Karthus Stats
7.3 6.6
Sett Stats


Karthus Stats
9.5 6.8
Sett Stats

Largest Killing Spree

Karthus Stats
2.8 2.6
Sett Stats

Damage Dealt

Karthus Stats
27401 18029
Sett Stats

Damage Taken

Karthus Stats
25090 30526
Sett Stats

Objective Stats

Towers Destroyed

Karthus Stats
5 5.5
Sett Stats

Inhibitors Destroyed

Karthus Stats
0.9 1
Sett Stats

Dragons Killed

Karthus Stats
1.8 2.1
Sett Stats

Barons Killed

Karthus Stats
0.4 0.4
Sett Stats

Gold Earned

Karthus Stats
11684 10776
Sett Stats

Minions Killed

Karthus Stats
77 116
Sett Stats

Karthus often has a similar longest kill spree as his opponent does. Typically, Karthus takes less damage than Sett. This commonly reflects different amounts of tankyness, but it can also show that the champion with more health has less mobility and thus is not able to escape additional damage when poked or engaged.

In Karthus vs Sett matchups, Karthus typically takes fewer minion kills than Sett. Champs that do not get many minion kills usually do not need much CS to be useful. Instead, they are capable of scaling easily off of their abilities alone. However, champions with large amounts of CS, such as ADCs, typically need a lot of items to be useful. In either case, try to beat the averages shown here to do well.

If you need to see Karthus vs Sett tips and counter stats for a a distinct player tier, please select one from the selection menu above. If viewing for the first time, the statistics and strategies given are computed using every match completed with these champions.

How We Analyze Our Matchups

For this counter guide, we analyzed 17235 Karthus vs Sett matchups from recent LoL games. We use rigorous data cleaning and processing methods to ensure that our counter stats are of the highest quality. You can rest assured that the recommended build to counter Sett as Karthus comes from real data and is not the fabrication of some random LoL player, as some other sites provide. You can use the filters at the top of the page to view the most relevant stats and items to your rank.