Try to take Vladimir down before Hemoplague detonates, as it will heal him for each afflicted enemy Champion.
Making Vladimir use Sanguine Pool at the start of a fight will maximize the Health cost of the ability to him.
Items that counter Health stacking, such as Liandry's Torment and Blade of the Ruined King, are very effective against Vladimir.
The stat comparisons shown here emphasize several important Senna versus Vladimir matchup stats that can help you explain the distinctions between the two. As an example, Senna’s KDA ratio ([kills + assists] / deaths) of NaN is better than Vladimir’s ratio of NaN, showing that Senna may be more central to her team's team fighting potential than Vladimir. This observation is largely fueled by the differences in assists.
Senna usually has a slightly smaller longest kill spree than her opponent does. Typically, she receives less damage than Vladimir. This is usually reflective of differing health capacities; however, it can also indicate that the champion with more health has less mobility and thus is not able to flee from further damage when engaged or poked.
Both League of Legends champions are great. Both champs have their strengths, weaknesses, and counters. In the game's current meta, Senna usually fairs equally well when facing off against Vladimir, with a 49.6% win rate. As a result, Senna makes an ok counter to Vladimir.
While Senna does have a lower win rate than Vladimir, when on opposite teams, Senna also has a greater learning curve that makes her a more time consuming character to develop with. You still need to be cautious when picking Senna into Vladimiras her relative depth means you may not be able to unleash her full potential without a lot of practice beforehand.
Furthermore, Senna also has a good amount of CC and other utility, a similar amount to Vladimir. This makes her just as valuable during teamfights, especially when fighting champions with a ton of burst damage.
While there isn't one best champion overall in League of Legends, in Senna vs Vladimir matchups, Vladimir is the better champ with a similar win rate, similar champion depth, and a similar amount of utility to help out your allies during teamfights.
Senna is a somewhat poor counter to Vladimir. Focus your strategy on increasing your CS and destroying objectives. If you can do that, you should be able to stand on your own as Senna against Vladimir.
To truly master Senna in order to counter Vladimir during both the lane and mid / late game phases of League of Legends, you should continue reading to learn a few extra tricks and insights into this matchup. If you listen to the build and stats shown here, you will grow your win rate significantly and be that much closer to League of Legends pro players.
Senna usually accumulates a lot less CS relative to Vladimir. Champs who typically don't acquire much CS usualy don't have to have much CS to be valuable teammates, such as sup champs. These kinds of champions are able to scale well off of their abilities and first items alone. Yet, champions with a lot of CS, such as hyper-carries, often have to have several high cost items to be effective. In either situation, try to surpass the values displayed here to do well.
The ideal items to use in your Senna versus Vladimir build include Eclipse, Rapid Firecannon, and Umbral Glaive. When Senna incorporated at least these three pieces in her build, she did much better when fighting Vladimir than with many other typical item sets. In fact, Senna boasted an average winrate of 49.6% battling Vladimir with these items in her kit.
To have the highest probability of coming out on top against Vladimir as Senna, you should use the Fleet Footwork, Presence of Mind, Legend: Alacrity, Cut Down, Bone Plating, and Revitalize runes from the Precision and Resolve rune sets. Out of all the rune combinations that we analyzed for Senna vs Vladimir counter picks, this blending of runes yielded the best win rate. Notably, these runes provided a 49.6% winrate overall.
If you need to get Senna versus Vladimir tips and matchup stats and build suggestions for a a distinct player tier, feel free to select one from the selection menu above. By default, the stats and guides displayed are computed using all games with data with both champions.