Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Follow your Blood Hunt trails to low health enemy champions.
Jaws of the Beast (Q) will follow enemies who run, dash or teleport if you keep the button held down.
Infinite Duress (R)'s distance scales with any Move Speed you gain, even from ally buffs and summoner spells.
The Karthus Warwick synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Warwick, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Warwick. His KDA worsened from NaN to NaN. This decrease shows that Warwick helps Karthus perform poorer in ranked League of Legends games. Yet, the small difference indicates that this performance change is only marginal.
When Karthus tries to synergize with Warwick, he gets a little increase in his complete damage output. This may signal that Warwick provides cover for him to deal more damage or that his presence on the team also helps extend the game's duration. Similarly, when Karthus is played together with Warwick on the same side, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing synergisticly with Warwick.
Additionally, when Karthus plays with Warwick on the same side, he on average takes less damage than when he plays alone. Taking not as much damage may indicate that Warwick does a decent job of covering Karthus during teamfights.
There is no ideal champion pairing for Karthus that will always be his top teammate. However, overall, Warwick is a pretty good teammate for Karthus. By being on the same team as Karthus, he raises their win rate by 1.8% to 50.8%. This clearly indicates that there is a potentially meaningful strategic relationship between Karthus and Warwick that allows them to perform stronger together than without each other.
Warwick has a much lower diffuclty than Karthus. That means you don't need to be cautious when enlisting Warwick allies to fight alongside, as they will require a much lower level of skill to fight well with you.
Playing on the same side, Karthus players will likely see an overall large increase in your team’s ability to deal magic damage. Combined, these champions can deal quite a lot of AP type damage.
Conversely, by bringing Karthus and Warwick together, you probably will not be giving your other teammates a lot of cover. Make sure to have other champions on your team that neutralizes this relative hole in their capabilities.
Regardless of your Warwick ally's skill level, you need to focus on maximizing your gold income, outlasting your enemies, and taking down objectives. If you do this, you should do well, regardless.
If you would like to truly master Karthus in order to work well with Warwick during both the lane and mid / late game phases of League of Legends rounds, you should continue reading to learn additional tricks and insights into this champion pairing. If you use the build and stats displayed here, you should increase your win rate by a lot.
The most important items to get in your Karthus and Warwick synergy build consist of Liandry's Anguish, Rabadon's Deathcap, and Shadowflame. When Karthus incorporated at least these three items in his build, he did a lot better when paired up with Warwick than with many other common builds. In fact, Karthus had an average winrate of 50.8% helping carry Warwick with these items in his kit.
To have the greatest probability of vanquishing your oponents, Karthus players should use the Dark Harvest, Taste of Blood, Eyeball Collection, Ultimate Hunter, Presence of Mind, and Last Stand runes from the Domination and Precision rune sets. Out of all the runes players chose for this champion pairing, this composite of runes yielded the top win rate. Notably, these runes provided a 50.8% win rate overall.
By default, tips, statistics, and builds on how to pair Warwick with Karthus are displayed for all ranked divisions combined. To scope the stats and builds to an individual rank, you can use the selection menu located earlier on the page.