Transfusion instantly deals damage to the enemy before healing Vladimir, making it one of the best last hitting tools in the game.
Cast Hemoplague where it will afflict the most units.
Sanguine Pool pops incoming missiles, so it can be used to dodge disables.
Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The Vladimir Cassiopeia synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Cassiopeia, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Vladimir sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Cassiopeia. His KDA decreased from NaN to NaN. This negative change shows that Cassiopeia helps Vladimir perform not as well in ranked League of Legends games. Yet, the small difference demonstrates that this performance change is not very impactful.
When Vladimir plays on the same team as Cassiopeia, he sees a small decrease in his complete damage output. This change could indicate that Cassiopeia does not support by providing protection for him to deal more damage or that her presence also helps increase the match's duration. Similarly, when Vladimir is played alongside Cassiopeia on the same side, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing synergisticly with Cassiopeia.
Moreover, when Vladimir plays with Cassiopeia on the same team, he usually takes a little less damage than when he plays alone. Getting dealt not as much damage could mean that Cassiopeia does a decent job of covering Vladimir in team fights.
There is no ideal champion pairing for Vladimir that will 100% of the time be his top synergy. Yet, overall, Cassiopeia is a good ally for Vladimir. By being on the same team as Vladimir, she improves their win rate by 1.9% to 51.9%. This shows that there is a good strategic relationship between Vladimir and Cassiopeia that results in them performing stronger together than without each other.
Cassiopeia has a greater difficulty than Vladimir. That means you should be cautious when finding Cassiopeia comrades to fight alongside, as they will have to have a greater level of skill to be able to work well with you.
When playing cooperatively, Vladimir players should expect to see an overall large increase in your team’s capability to deal magic damage. When paired, these two can blast through enemies with magic damage.
Conversely, by bringing Vladimir and Cassiopeia together, you probably will not be giving your other teammates much attack damage. Plan to include other champions on your team that helps cover this disparity in their capabilities.
Regardless of your Cassiopeia ally's ability, you need to focus on maximizing your income, warding to avoid ambushes, and clearing objectives. If you do this, you will do well, regardless.
To truly master Vladimir to pair well with Cassiopeia during both the early game and mid / late game phases of League rounds, you should continue reading to pick up some more tricks and insights into this champion pairing. If you pay attention to the build and stats displayed here, you will grow your win rate significantly.
The most crucial items to build first in your Vladimir and Cassiopeia synergy build include Rabadon's Deathcap, Riftmaker, and Liandry's Torment. When Vladimir incorporated at least these three finished items in his build, he did a lot better as an ally of Cassiopeia than with most other common builds. In fact, Vladimir boasted an average win rate of 51.9% helping carry Cassiopeia with these items in his kit.
To have the best chance of annihilating your oponents, you should take the Phase Rush, Nimbus Cloak, Transcendence, Gathering Storm, Cosmic Insight, and Magical Footwear runes from the Sorcery and Inspiration rune sets. Of all the rune sets that we analyzed for this champion pairing, this sequence of runes resulted in the greatest win rate. Notably, these runes provided a 51.9% winrate overall.
If you want to see Vladimir and Cassiopeia collaboration tips and stats for a an individual division rank, feel free to choose one from the selection menu above. If viewing for the first time, the stats and build suggestions given are calculated using every match finished with both champions.