Sanguine Pool pops incoming missiles, so it can be used to dodge disables.
Transfusion instantly deals damage to the enemy before healing Vladimir, making it one of the best last hitting tools in the game.
Cast Hemoplague where it will afflict the most units.
Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The Vladimir Vayne synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Vayne, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Vladimir sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Vayne. His KDA went down from NaN to NaN. This drop shows that Vayne helps Vladimir perform poorer in competitive League of Legends matches. Yet, the small difference demonstrates that this performance change is not very impactful.
When Vladimir is an ally to Vayne, he gets a small increase in his complete damage dealt. This may demonstrate that Vayne helps provide protection for him to dish out more damage or that her presence also helps increase the round's duration. Similarly, when Vladimir is played with Vayne on the same side, he usually scores many fewer killing sprees than when he plays without Vayne. This is contrasting evidence that he is worse when playing with Vayne.
Moreover, when Vladimir plays with Vayne on the same team, he typically receives a little more damage than when he plays alone. Taking more damage could indicate that Vayne does a poor job of covering Vladimir in teamfights.
There is no top champion pairing for Vladimir that will always be his top ally. However, Vayne is a decent companion for Vladimir. By being on the same team as Vladimir, she improves their win rate by 2.5% to 52.6%. This proves that there is a potentially meaningful synergy between Vladimir and Vayne that results in them performing stronger together than without each other.
Vayne has a greater difficulty than Vladimir. That means you must be cautious when enlisting Vayne allies to fight alongside, as they will have to have a greater level of skill to be able to fight well with you.
Fighting together, you should expect to witness an overall large increase in your team’s capacity to destroy wih physical damage. When paired, these champions should be able to take down targets with auto-attacks and other AD damage abilities.
Although, by bringing Vladimir and Vayne together, you may not be giving your side a lot of support. We recommend you have other champs on your team that nullifies this relative hole in this pairing's potential.
Regardless of your Vayne ally's ability, you need to focus on maximizing your income, outlasting your enemies, and clearing objectives. If you heed this simple advice, you should do well anyway.
If you would like to truly master Vladimir to synergize with Vayne during both the lane and mid / late game phases of LoL games, you should keep reading to learn a few extra tips and tricks for this champion pairing. If you pay attention to the build and suggestions shown above, you will increase your win rate significantly.
The most crucial finished items to have in your Vladimir and Vayne synergy build consist of Hextech Rocketbelt, Rabadon's Deathcap, and Zhonya's Hourglass. When Vladimir used at least these three finished items in his build, he did much better as an ally of Vayne than with most other common item sets. In fact, Vladimir boasted an average win rate of 52.6% helping carry Vayne with these items in his kit.
To have the best probability of defeating your oponents, Vladimir players should take the Phase Rush, Nimbus Cloak, Transcendence, Gathering Storm, Cosmic Insight, and Magical Footwear runes from the Sorcery and Inspiration rune sets. Of all the rune builds that we analyzed for this team composition, this mix of runes yielded the highest win rate. Moreover, these runes gave a 52.6% winrate overall.
By default, tips, statistics, and builds on how to pair Vayne with Vladimir are displayed for all skill levels combined. To filter the stats and builds to an individual skill level, you can use the selection menu located earlier in the counter matchup guide.