Placing a Living Shadow before using Death Mark can give Zed a safe escape from combat.
Quickly double tapping Living Shadow will teleport Zed to his shadow immediately for rapid escapes.
Saving energy and spell cooldowns until you use your ultimate will maximize Death Mark's damage.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Zed Karthus synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Karthus, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Zed sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA went down from NaN to NaN. This negative change shows that Karthus helps Zed perform poorer in ranked LoL games. Yet, the small difference demonstrates that this performance change is not very impactful.
When Zed tries to synergize with Karthus, he sees a marginal improvement in his full damage dealt. This difference could indicate that Karthus helps provide protection for him to dish out more damage or that his presence on the team also helps extend the round's duration. Similarly, when Zed is played alongside Karthus on the same side, he usually scores many fewer killing sprees than when he plays on his own. This is contrasting evidence that he is worse when playing alongside Karthus.
Moreover, when Zed plays with Karthus on the same team, he on average takes a little more damage than when he plays alone. Receiving more damage may mean that Karthus does a poor job of protecting Zed during team fights.
There is no perfect ally for Zed that will no matter what be his ideal ally. However, overall, Karthus is a very typical teammate for Zed. By being on the same side as Zed, he drops their win rate by -0.3% to 48.1%. This shows that there is only a small synergy between Zed and Karthus that allows them to perform worse together than alone.
Karthus has a lower difficulty than Zed. That means you don't need to be careful when enlisting Karthus comrades to go into battle on the same side as, as they will need a relatively low level of skill to play well with you.
Fighting together, Zed players should see an overall large increase in your team’s capacity to destroy wih physical damage. When paired, these champs can provide a great amount of sustained physical damage.
In contrast, by grouping Zed and Karthus together, you probably will not be granting your other teammates a great deal of cover. Plan to pick other champs on your team that fills this disparity in this pairing's playstyle.
Regardless of the ability of your Karthus ally, you should focus on increasing your gold income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you should do well anyway.
If you would like to learn all of the intricacies of Zed to work well with Karthus during both the lane and mid / late game phases of LoL matches, you should keep reading to learn additional tricks and insights into this champion pairing. If you listen to the build and suggestions presented above, you will grow your win rate by a lot.
The best items to have in your Zed and Karthus synergy build consist of Duskblade of Draktharr, Youmuu's Ghostblade, and Serylda's Grudge. When Zed included at least these three finished items in his build, he did much better as an ally of Karthus than with most other commonly used builds. In fact, Zed boasted an average win rate of 48.1% when synergizing his build and playstyle to Karthus with this build.
To have the highest likelihood of crushing your oponents, Zed players should equip the Electrocute, Taste of Blood, Eyeball Collection, Ultimate Hunter, Transcendence, and Scorch runes from the Domination and Sorcery rune sets. Of all the rune builds players picked for this champion pairing, this blending of runes resulted in the highest win rate. Notably, these runes gave a 48.1% winrate overall.
If you need to view Zed and Karthus collaboration tips and stats for a an individual rank, feel free to choose one from the selection menu provided above. At first, the statistics and guides given are computed using every game with data with these champs.