Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Get boots early when playing against Syndra, they'll help you avoid many of her spells.
At max rank Syndra's spells gain bonus effects and change in appearance.
Attack Syndra after she's used Scatter the Weak, it has a long cooldown so she'll be vulnerable.
The stat comparisons shown here highlight some vital Karthus versus Syndra matchup statistics that can help us realize the distinctions between the two. Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Syndra’s ratio of NaN, indicating that Karthus may be more central to his team's team fighting capacity than Syndra..
Karthus normally has a slightly larger longest killing spree than his counter does. Commonly, he receives more damage than Syndra. This is usually reflective of differing health capacities, but it can also indicate that the one champion has less agility and thus is unable to kite away from further harm when engaged or poked.
Both League of Legends champs are great champions. Both champs have their pros and cons. In the game's current meta, Karthus usually wins when playing against Syndra, with a 51.2% win rate. Thus, Karthus makes a good counter for Syndra.
While Karthus does have a higher win rate than Syndra, when on opposite teams, Karthus also has a lower difficulty level that makes him a less time consuming champ to develop with. You should be careful when picking Karthus into Syndraas his relative depth means that you may not be able to unleash his full potential without a lot of practice beforehand.
Moreover, Karthus has some amount of CC and other utility, a similar amount to Syndra. This makes her just as valuable during team fights, especially when trying to counter champions with a lot of burst damage.
While there is not a single best champion in League of Legends, in Karthus vs Syndra matchups, Karthus is the better champion with a higher win rate, less champion complexity, and a similar amount of utility to help out your teammates during team fights.
Karthus is a decent counter to Syndra. You will do well by focussing your actions on keeping up your CS and taking out objectives. If you do that, you should hold your own as Karthus against Syndra.
If you would like to truly master Karthus to counter Syndra during both the laning and mid / late game phases of League of Legends, you should keep reading to learn a few extra tricks and insights into this matchup. If you mind the build and stats shown here, you will grow your win rate by a lot and be that much closer to League of Legends pro players.
Karthus often racks up less CS compared to Syndra. Champs who typically don't acquire many minion kills usualy don't have to have much CS to be valuable teammates, such as sup champs. These kinds of champions are capable of scaling well off of their abilities and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, usually have to have a lot of items to be effective. In either situation, try to exceed the values displayed on this page to do well.
The most important items to have in your Karthus versus Syndra build include Liandry's Anguish, Zhonya's Hourglass, and Shadowflame. When Karthus combined at least these three pieces in his build, he did much better versus Syndra than with many other commonly used builds. In fact, Karthus boasted an average winrate of 51.2% battling Syndra with this build.
To have the highest probability of vanquishing Syndra as Karthus, you should equip the Dark Harvest, Taste of Blood, Eyeball Collection, Ultimate Hunter, Presence of Mind, and Last Stand runes from the Domination and Precision rune sets. Of all the rune builds we have analyed for Karthus vs Syndra counters, this mixture of runes yielded the greatest win rate. Notably, these runes provided a 51.2% winrate overall.
If you want to get Karthus x Syndra tips and matchup stats and build suggestions for a a distinct player tier, feel free to select one from the selection menu above. If viewing for the first time, the stats and guides shown are calculated using every match completed with these champions.