Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Storing a stun for use with her ultimate can turn the tide of a team fight.
Transfusion instantly deals damage to the enemy before healing Vladimir, making it one of the best last hitting tools in the game.
Cast Hemoplague where it will afflict the most units.
Sanguine Pool pops incoming missiles, so it can be used to dodge disables.
The Annie Vladimir synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Vladimir, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Annie sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Vladimir. His KDA went down from NaN to NaN. This worsening shows that Vladimir helps Annie perform poorer in ranked League of Legends games. Yet, the small difference proves that this performance change is not very impactful.
When Annie is an ally to Vladimir, she sees a noticable drop in her full damage output. This change could demonstrate that Vladimir does not provide cover for her to dish out more damage or that his support also helps extend the match's duration. Similarly, when Annie is played alongside Vladimir on the same team, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing synergisticly with Vladimir.
Additionally, when Annie plays with Vladimir on the same team, she usually takes a little more damage than when she fights alone. Taking more damage could mean that Vladimir does a poor job of covering Annie in team fights.
There is no ideal synergy for Annie that will no matter what be her ideal synergy. However, overall, Vladimir is a terrible companion for Annie. By being on the same side as Annie, he drops their win rate by -5.2% to 45.6%. This clearly indicates that there is an easy to overcome and exploit bond between Annie and Vladimir that results in them performing not as well together than alone.
Vladimir has a greater difficulty than Annie. That means you must be careful when arranging Vladimir comrades to go into battle on the same side as, as they will need a greater level of skill to be able to fight well with you.
Working cooperatively, you should expect to see an overall large increase in your team’s ability to deal magic damage. Together, these two can deal quite a lot of AP type damage.
In contrast, by grouping Annie and Vladimir together, you will not be providing your other allies a great deal of attack damage. Plan to bring other champs on your team that offsets this gap in this pairing's capabilities.
Regardless of your Vladimir ally's skill level, you should focus on maximizing your income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you should do well anyway.
If you would like to truly master Annie in order to synergize with Vladimir during both the early game and mid / late game phases of LoL matches, you should keep reading to master additional lessons on this champion pairing. If you use the build and suggestions displayed above, you will increase your win rate by a lot.
The most crucial items to get in your Annie and Vladimir synergy build consist of Liandry's Anguish, Rabadon's Deathcap, and Shadowflame. When Annie included at least these three finished items in her build, she did much better as an ally of Vladimir than with many other commonly used builds. In fact, Annie boasted an average win rate of 45.6% when synergizing her build and playstyle to Vladimir with these items in her kit.
To have the best likelihood of coming out on top against your oponents, you should equip the Electrocute, Cheap Shot, Eyeball Collection, Relentless Hunter, Manaflow Band, and Absolute Focus runes from the Domination and Sorcery rune sets. Out of all the runes we have analyed for Annie and Vladimir pairings, this sequence of runes yielded the top win rate. In fact, these runes averaged a 45.6% winrate overall.
By default, tips, statistics, and builds on how to team up Vladimir with Annie are presented for all skill levels, merged. To scope the statistics and builds to a specific skill level, you may use the selection menu located earlier on the page.