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How to Synergize Karthus with Seraphine on the Same TeamKarthus is in the b tier of champions

Karthus with Seraphine

How to Win With Karthus and Seraphine Paired TogetherKarthus is in the b tier of champions
Mage
MageSupport

How to Synergize Karthus and Seraphine

based on 1,645 Karthus with Seraphine pairs
Win Rate
46.5 %
K/D/A
2.13
Pick Rate
3.4 %

How We Analyze Champion Pairings in LoL

At MOBA Champion, we take in data from from millions of League games straight from Riot Games each week. Karthus has fought alongside Seraphine in 1645 recent, ranked games. By amassing so much great data straight from the creators of League, we are sure that we can produce high-quality, accurate builds to help Karthus synergize with Seraphine. It is relatively rare for Karthus to play alongside Seraphine on the same team. This has only happened in about 3.4% of rounds with Karthus.

Karthus Seraphine Synergy Summary

Unfortunately, Karthus has done a terrible job of teaming up with Seraphine. Usually, he wins a dismal 46.5% of the time the champions try and synergize their gameplay. If you want to maximize your potential as Karthus when playing alongside Seraphine by learning how to better synergize your play style with her, then review the full build (with items, runes, summoner spells, and skills) below!

Best Karthus vs Seraphine Counter Build

Items

Starter Items

Time Target
Scorchclaw PupHealth Potion

Early Items

~5 Mins
BootsLost Chapter

Core Karthus Items

~22 Mins
MalignanceVoid StaffShadowflame

Optional Items

Rabadon's DeathcapLiandry's TormentStormsurgeLuden's Companion

Summoner Spells

summonerexhaust summoner spell D
summonersmite summoner spell F

Skill Order

First skill for Karthus to level upq
>
Second ability for Karthus to level upe
>
Last skill for Karthus to max outw

Runes

DominationDark HarvestCheap ShotEyeball CollectionUltimate Hunter
SorceryTranscendenceGathering Storm
Adaptive ForceAdaptive ForceArmor
Karthus's passive ability p
Karthus's q ability q
Karthus's w ability w
Karthus's e ability e
Karthus's ultimate ability r
1
Q
2
E
3
Q
4
W
5
Q
6
R
7
Q
8
E
9
Q
10
E
11
R
12
E
13
E
14
W
15
W
16
R

Guide to Synergizing Karthus and Seraphine

Tips for Playing as Karthus with Seraphine

Lay Waste is very strong at farming minions and harassing enemy champions.

Ask your allies to help point out when you should use Requiem to get kills in different lanes.

Karthus Seraphine Synergy Stats

Karthus Image
Win Rate
46.5 %
VS
Win Rate
53.5 %
Seraphine Image
7.1
< Kills >
7
7.7
< Deaths >
7.6
9.3
< Assists >
9.5
1.64
< Killing Sprees >
1.63
83
< Minions Killed >
88
0.94
< Dragons Killed >
0.89
0.28
< Inhibitors >
0.28
264
< Physical Damage >
246
29,074
< Magic Damage >
29,153
2,129
< True Damage >
2,031
31,467
< Damage Dealt >
31,430
30,626
< Damage Taken >
29,785
12,851
< Gold Earned >
12,799
1.09
< Towers >
1.08
0.24
< Baron Takedowns >
0.23
9,828
< Total Healing >
9,279
14,930
< Experience >
14,921
18
< Vision Score >
19
7
< Wards Placed >
7
226
< Time Dealing CC >
221

How to Play with Seraphine as Karthus in LoL

The Karthus Seraphine synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Seraphine, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.

Overall, Karthus sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Seraphine. His KDA fell from NaN to NaN. This drop shows that Seraphine helps Karthus perform not as well in competitive LoL games. Yet, the small difference demonstrates that this performance change is not very impactful.

When Karthus is paired with Seraphine, he gets a marginal improvement in his total damage dealt. This could indicate that Seraphine provides protection for him to deal more damage or that her support also helps increase the game's duration. Similarly, when Karthus is played alongside Seraphine on the same team, he usually scores many fewer killing sprees compared to when he plays alone. This is contrasting evidence that he is worse when playing with Seraphine.

Moreover, when Karthus plays with Seraphine on the same side, he typically takes a little more damage than when he fights alone. Taking more damage could indicate that Seraphine does a poor job of protecting Karthus during teamfights.

Synergies between Karthus and Seraphine

Damage Types Compared

Karthus
Seraphine
Physical Damage
Magic Damage
True Damage

Champion Playstyles Contrasted

Karthus
Seraphine

Is Karthus better when played alongside Seraphine?

There is no universally accepted best companion for Karthus that will 100% of the time be his #1 teammate. Yet, overall, Seraphine is a very typical teammate for Karthus. By playing on the same team as Karthus, she drops their win rate by -0.8% to 46.5%. This clearly indicates that there is not really a strong bond between Karthus and Seraphine that results in them performing worse together than without each other.

Seraphine has a much lower diffuclty than Karthus. That means Karthus players don't need to be careful when finding Seraphine allies to play with, as they will need a much lower level of skill to be able to cooperate well with you.

Playing cooperatively, you will likely observe an overall large increase in your team’s capacity to buff allies and debuff enemies. Together, these two should be able to manipulate the pace of team fights.

In contrast, by pairing Karthus and Seraphine together, you probably will not be giving your team much attack damage. We recommend you include other champs on your team that nullifies this gap in their kit.

Regardless of your Seraphine ally's ability, you need to focus on increasing your gold income, warding to avoid ambushes, and clearing objectives. If you do this, you will do well, regardless.

Additional Information for Karthus Players

How We Calculated Our Karthus Seraphine Synergy Build and Stats

For this guide on pairing Karthus and Seraphine, we analyzed 1,645 ranked and recent League of Legends matches. We perform advanced data cleaning and statistical methods to guarantee that our team synergy stats are accurate and reliable. You can be confident that our recommended build to pair Karthus with Seraphine comes from actual data and is not the fabrication of some random LoL player, as some other sites provide. You can use the filters at the top of the page to view your division's most relevant stats and build.

Other Useful Resources

Further Insights to Win with this Champion Pairing

To truly master Karthus to work well with Seraphine during both the lane and mid / late game phases of League, you should keep reading to pick up some more lessons on this champion pairing. If you pay attention to the build and stats shown here, you will grow your win rate by a lot.

The most important finished items to use in your Karthus and Seraphine synergy build include Malignance, Void Staff, and Shadowflame. When Karthus bought at least these three pieces in his build, he did significantly better when fighting alongside Seraphine than with many other commonly used item sets. In fact, Karthus boasted an average win rate of 46.5% helping carry Seraphine with these items in his kit.

To have the best likelihood of crushing your oponents, Karthus players should equip the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Gathering Storm, and Transcendence runes from the Domination and Sorcery rune sets. Out of all the runes players picked for Karthus and Seraphine pairings, this composite of runes resulted in the highest win rate. Notably, these runes gave a 46.5% win rate overall.

If you need to get Karthus with Seraphine collaboration tips and stats for a a specific division rank, please choose one from the selection menu above. By default, the stats and strategies displayed are computed using every match completed with both champs.